{"id":"W2621601071","doi":"10.1007/s00125-017-4331-2","title":"High glucose increases the formation and pro-oxidative activity of endothelial microparticles","year":2017,"lang":"en","type":"article","venue":"Diabetologia","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Institute of Circulatory and Respiratory Health; Canadian Institutes of Health Research; Pfizer Canada; Kidney Foundation of Canada; Diabetes Canada; Heart and Stroke Foundation of Canada; Pfizer; Ottawa Hospital Research Institute; Canadian Diabetes Association","keywords":"Reactive oxygen species; Oxidative stress; Flow cytometry; Chemistry; Endothelial dysfunction; Endothelial stem cell; Microvesicles; Diabetes mellitus; Endothelium; Internal medicine; Endocrinology; Biochemistry; Biology; Medicine; Immunology; In vitro; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001645464,0.0002913539,0.0002252232,0.0001980459,0.0001148341,0.0004676843,0.0001087917,0.0003457382,0.001130817],"category_scores_gemma":[0.0002490838,0.0001192763,0.0003022948,0.0001448207,0.0001290181,0.0003024949,0.0002441846,0.0004447518,0.0002162218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001919689,"about_ca_system_score_gemma":0.00009872516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004357219,"about_ca_topic_score_gemma":0.0002671225,"domain_scores_codex":[0.9998274,0.00003992744,0.00001532568,0.00002437113,0.00003412785,0.00005881813],"domain_scores_gemma":[0.9998273,0.00004534077,0.0000437246,0.00001781561,0.00001998206,0.00004576241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002930689,0.000155562,0.001419559,0.00007429574,0.00003727888,0.000177227,0.00003826901,0.00007006228,0.9907664,0.0001374633,0.0001463285,0.004046764],"study_design_scores_gemma":[0.00006825907,0.001152413,0.03075185,0.00001449173,0.00006365964,0.0003278066,0.00008259678,0.0005888487,0.9653045,0.0001397967,0.001491603,0.00001428887],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954999,0.002698023,0.0009331057,0.00009266273,0.00008499058,0.000008550712,0.0001826024,0.00002332968,0.0004768552],"genre_scores_gemma":[0.9972733,0.0008109745,0.0004061425,0.00005129734,0.00003493187,0.00001235811,0.00027951,0.000007997636,0.001123618],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001130817,"threshold_uncertainty_score":0.003782988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01256654428730515,"score_gpt":0.2548779452301811,"score_spread":0.242311400942876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}