{"id":"W2621746631","doi":"10.1002/hon.2437_3","title":"INTERIM REPORT FROM A PHASE 2 MULTICENTER STUDY OF TAZEMETOSTAT, AN EZH2 INHIBITOR, IN PATIENTS WITH RELAPSED OR REFRACTORY B‐CELL NON‐HODGKIN LYMPHOMAS","year":2017,"lang":"en","type":"article","venue":"Hematological Oncology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Medicine; Tolerability; Internal medicine; Oncology; Clinical endpoint; Interim analysis; Ixazomib; Phases of clinical research; Adverse effect; EZH2; Surrogate endpoint; Pharmacology; Refractory (planetary science); Clinical trial; Lenalidomide; Multiple myeloma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002932874,0.0002247572,0.0005415939,0.0000635349,0.00009636719,0.00002314365,0.0003321107,0.0003689448,0.00007007532],"category_scores_gemma":[0.0004005828,0.0001566372,0.0000548075,0.00004704782,0.0001735803,0.00001542581,0.0002402379,0.0001575835,0.000003716997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004601259,"about_ca_system_score_gemma":0.0001359931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002784412,"about_ca_topic_score_gemma":0.0009075002,"domain_scores_codex":[0.9979926,0.0002565724,0.0006747858,0.0006237236,0.0001878866,0.0002644418],"domain_scores_gemma":[0.9980131,0.00006580142,0.0007363228,0.0008908177,0.0001688299,0.0001250614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009051492,0.02084004,0.8527355,0.00002406186,0.00007524042,0.0007117746,0.0005547511,0.00001253313,0.1099398,0.000002490182,0.0001107581,0.005941505],"study_design_scores_gemma":[0.04372595,0.05616002,0.7041929,0.00005731578,0.0001020293,0.00001145077,0.0009112536,0.0001435876,0.1861034,0.00006601617,0.007953285,0.0005727664],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998085,0.00007316995,0.0002390168,0.00002711006,0.0002077549,0.0006523165,0.00002030857,0.00000850331,0.0006868452],"genre_scores_gemma":[0.9977568,0.00002546357,0.00172285,0.00005472752,0.00005920285,0.0000556043,0.0002317717,0.00002272697,0.00007084936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1485426,"threshold_uncertainty_score":0.6387478,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03091780164131205,"score_gpt":0.3516476903810811,"score_spread":0.320729888739769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}