{"id":"W2621884886","doi":"10.1016/j.celrep.2017.05.049","title":"Androgen Receptor Deregulation Drives Bromodomain-Mediated Chromatin Alterations in Prostate Cancer","year":2017,"lang":"en","type":"article","venue":"Cell Reports","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":134,"is_retracted":false,"has_abstract":true,"ca_institutions":"Genome British Columbia","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; National Cancer Institute; National Institutes of Health; Norges Idrettshøgskole; University Hospitals; Medical Research Council; Innovative Medicines Initiative; Ministero dello Sviluppo Economico; AbbVie; Novartis Pharma; Canada Foundation for Innovation; Merck; Ontario Ministry of Economic Development and Innovation; Boehringer Ingelheim; Shenzhen Gas Corporation; Wellcome Trust; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Norges Forskningsråd; Kreftforeningen; European Federation of Pharmaceutical Industries and Associations; Takeda Pharmaceutical Company; Wellcome; Pfizer; Janssen Pharmaceuticals; Prostate Cancer Foundation","keywords":"Prostate cancer; Androgen receptor; Chromatin; Bromodomain; Enzalutamide; Deregulation; Cancer research; Prostate; Receptor; Androgen; Cancer; Cell biology; Epigenetics; Biology; Chemistry; Medicine; Internal medicine; Endocrinology; Hormone; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001974405,0.0001196728,0.0001636895,0.0001991991,0.0001070701,0.0002674499,0.00008659563,0.00009122027,0.001400763],"category_scores_gemma":[0.00009416384,0.0001077783,0.0001650708,0.0001604828,0.0001566388,0.00006958876,0.0001279601,0.000262495,0.0002372882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002603053,"about_ca_system_score_gemma":0.0002331372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007981992,"about_ca_topic_score_gemma":0.002009473,"domain_scores_codex":[0.9998993,0.00001969027,0.000008486012,0.00001649699,0.00003048374,0.00002559728],"domain_scores_gemma":[0.9999472,0.00001271118,0.00001307302,0.000007835134,0.000004123363,0.00001500386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006922161,0.00002894229,0.0006963543,0.00002190424,0.000007343581,0.00004096358,0.000009443715,0.00008660304,0.9968027,0.000134932,0.00006977822,0.002031739],"study_design_scores_gemma":[0.00002750077,0.0006787464,0.0287915,0.000003509563,0.00003032447,0.0009153719,0.00004459114,0.001227774,0.9612061,0.00011468,0.006952654,0.000007304491],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934411,0.002546686,0.00156812,0.00009602459,0.00002574858,0.00002236734,0.0002814401,0.0001113658,0.001907209],"genre_scores_gemma":[0.9975305,0.000678077,0.0004515628,0.00003509019,0.000004375976,0.000007449737,0.0002326179,0.000007451102,0.001052782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001400763,"threshold_uncertainty_score":0.004686058,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008203622509549062,"score_gpt":0.2505070856334412,"score_spread":0.2423034631238921,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}