{"id":"W2621884886","doi":"10.1016/j.celrep.2017.05.049","title":"Androgen Receptor Deregulation Drives Bromodomain-Mediated Chromatin Alterations in Prostate Cancer","year":2017,"lang":"en","type":"article","venue":"Cell Reports","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":134,"is_retracted":false,"has_abstract":true,"ca_institutions":"Genome British Columbia","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; National Cancer Institute; National Institutes of Health; Norges Idrettshøgskole; University Hospitals; Medical Research Council; Innovative Medicines Initiative; Ministero dello Sviluppo Economico; AbbVie; Novartis Pharma; Canada Foundation for Innovation; Merck; Ontario Ministry of Economic Development and Innovation; Boehringer Ingelheim; Shenzhen Gas Corporation; Wellcome Trust; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Norges Forskningsråd; Kreftforeningen; European Federation of Pharmaceutical Industries and Associations; Takeda Pharmaceutical Company; Wellcome; Pfizer; Janssen Pharmaceuticals; Prostate Cancer Foundation","keywords":"Prostate cancer; Androgen receptor; Chromatin; Bromodomain; Enzalutamide; Deregulation; Cancer research; Prostate; Receptor; Androgen; Cancer; Cell biology; Epigenetics; Biology; Chemistry; Medicine; Internal medicine; Endocrinology; Hormone; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001341961,0.00009805465,0.00009169861,0.00003355325,0.0001769169,0.00007151911,0.00007695946,0.00007737079,0.00006899267],"category_scores_gemma":[0.0001414548,0.00009586653,0.00003681991,0.00003053652,0.0000578588,0.00001513238,0.0000536542,0.00004722731,0.000007646971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000217729,"about_ca_system_score_gemma":0.0001069641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001062546,"about_ca_topic_score_gemma":0.0002016903,"domain_scores_codex":[0.9991981,0.00003012383,0.0002597624,0.0002720676,0.00009773946,0.0001422474],"domain_scores_gemma":[0.9991493,0.000003644315,0.0002907586,0.0004402348,0.00005824926,0.00005782659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001469941,0.0000427744,0.03621517,0.00001298016,0.000007916879,0.00002145539,0.00008694891,0.00005214275,0.9585477,0.00000567537,0.003605091,0.001387405],"study_design_scores_gemma":[0.000319953,0.0000383067,0.02581093,0.00002908923,0.000004217696,0.00001387957,0.00002049459,0.0001158843,0.9430106,0.00007485441,0.03041454,0.0001472326],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996537,0.0003615192,0.00007984383,0.0003013798,0.0002647105,0.0003252102,0.00001058014,0.0000121804,0.002107612],"genre_scores_gemma":[0.9958744,0.0001353187,0.0004413591,0.00005523794,0.0001335957,0.00008903185,0.000375585,0.00001454114,0.002880913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02680945,"threshold_uncertainty_score":0.3909323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008203622509549062,"score_gpt":0.2505070856334412,"score_spread":0.2423034631238921,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}