{"id":"W2621961553","doi":"10.1200/jco.2017.35.15_suppl.549","title":"Toxicity of extended adjuvant aromatase inhibitors therapy in postmenopausal breast cancer patients: A systematic review and meta-analysis.","year":2017,"lang":"en","type":"review","venue":"Journal of Clinical Oncology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Breast cancer; Number needed to harm; Internal medicine; Discontinuation; Adverse effect; Tolerability; Odds ratio; Hazard ratio; Oncology; Aromatase inhibitor; Adjuvant therapy; Placebo; Cancer; Surgery; Number needed to treat; Relative risk; Confidence interval; Aromatase; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaepi_broad"],"consensus_categories":[],"category_scores_codex":[0.01051464,0.002143921,0.01478393,0.005300182,0.0004568582,0.002175869,0.001387033,0.001649191,0.002835873],"category_scores_gemma":[0.02169571,0.001211131,0.03353954,0.005626321,0.0005344073,0.00127581,0.001266076,0.001605813,0.0002282158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002225196,"about_ca_system_score_gemma":0.003253716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005329361,"about_ca_topic_score_gemma":0.0145728,"domain_scores_codex":[0.9929901,0.00312372,0.002200966,0.0006271229,0.0008572146,0.0002008167],"domain_scores_gemma":[0.9867566,0.008834213,0.002956833,0.0003461093,0.0008977081,0.0002084669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.002557277,0.00002804528,0.003515762,0.4625765,0.5172574,0.0001114882,0.00006415357,0.0004236123,0.0001797211,0.00009525565,0.0005492497,0.01264155],"study_design_scores_gemma":[0.0008884985,0.0002978842,0.004086018,0.03060311,0.9617036,0.0001321285,0.00003343682,0.0001552521,0.0000925439,0.0001592591,0.001825817,0.0000223651],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003821615,0.9946977,0.0003130598,0.0001446494,0.0000917264,0.0002432424,0.0004986587,0.00001437885,0.0001750101],"genre_scores_gemma":[0.1525639,0.8424314,0.00165277,0.0008567195,0.0002090313,0.001026929,0.0009128464,0.0000214034,0.0003250066],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9852161,"threshold_uncertainty_score":0.05560744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1314075737076167,"score_gpt":0.4839891607222014,"score_spread":0.3525815870145847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}