{"id":"W2622097897","doi":"10.1158/1557-3265.ovcasymp16-ap28","title":"Abstract AP28: <i>BRCA1</i> and <i>RAD51C</i> Promoter Hypermethylation Confer Sensitivity to PARP Inhibitors in Patients with Platinum Sensitive Ovarian Carcinoma","year":2017,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Princess Margaret Cancer Centre","funders":"","keywords":"Cancer research; Ovarian cancer; Loss of heterozygosity; Methylation; DNA methylation; Biology; Germline mutation; PARP inhibitor; Germline; Cancer; Oncology; Medicine; Mutation; Genetics; Gene; Poly ADP ribose polymerase; Polymerase; Gene expression; Allele","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002429225,0.0001579162,0.00028396,0.0003948752,0.0002122226,0.0003840764,0.0001517774,0.0002566766,0.001876613],"category_scores_gemma":[0.001332419,0.0001311734,0.0002287763,0.0003267823,0.0001512881,0.0002017871,0.0002033496,0.0003734172,0.0002563709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002386288,"about_ca_system_score_gemma":0.0001641961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001102865,"about_ca_topic_score_gemma":0.0008917438,"domain_scores_codex":[0.9997758,0.0000438761,0.00002287369,0.00008318554,0.00004143617,0.00003273644],"domain_scores_gemma":[0.9992872,0.000237729,0.0001824296,0.00004373062,0.0000833188,0.0001657474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001414143,0.00009349657,0.9855545,0.00001421661,0.00004702325,0.0004751545,0.0001042848,0.0001170466,0.007731892,0.00001802048,0.0002481429,0.004182113],"study_design_scores_gemma":[0.00003581009,0.0005369554,0.9957908,0.000002600271,0.00003672565,0.001355065,0.000108541,0.0003914876,0.001384287,0.00003826263,0.0003144196,0.000004976708],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994068,0.00008799644,0.00003886714,0.00002341804,0.000002893448,0.000005529992,0.0001670862,0.000004121175,0.0002633159],"genre_scores_gemma":[0.9996787,0.00001669676,0.00003609137,0.00001710134,0.000003715911,0.000004237737,0.0001325068,0.000001835965,0.0001090775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001876613,"threshold_uncertainty_score":0.006277919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07066324461844924,"score_gpt":0.4064281828950106,"score_spread":0.3357649382765614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}