{"id":"W2622233487","doi":"10.1039/c7sc01269a","title":"Multi-target-directed phenol–triazole ligands as therapeutic agents for Alzheimer's disease","year":2017,"lang":"en","type":"article","venue":"Chemical Science","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; Calgary Laboratory Services; Burnaby Hospital; Simon Fraser University; University of Calgary","funders":"Canada Research Chairs; National Institutes of Health; Alberta Prion Research Institute; Vetenskapsrådet; National Research Foundation of Korea; National Research Foundation; Alzheimer's Society; Canadian Institutes of Health Research; Alzheimer Society; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada; Michael Smith Health Research BC; National Institute on Aging; Alzheimer's Association","keywords":"Chemistry; Peptide; Combinatorial chemistry; Pharmacology; Toxicity; Triazole; Phenol; Biochemistry; Computational biology; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002181281,0.0001923206,0.0002369542,0.0000637788,0.0007649498,0.0001697978,0.000632617,0.0000565712,0.00015878],"category_scores_gemma":[0.0007325028,0.0001432497,0.0001551223,0.0001722828,0.001025986,0.0002933318,0.0001895328,0.0001192665,0.0001816526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008466156,"about_ca_system_score_gemma":0.0006575021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002599784,"about_ca_topic_score_gemma":4.84364e-7,"domain_scores_codex":[0.9978536,0.000007797526,0.0001689749,0.0005876289,0.0006779981,0.0007039778],"domain_scores_gemma":[0.9973755,0.00005882823,0.00009316757,0.0007983551,0.0002349489,0.001439218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006925546,0.009068991,0.2141222,0.0002440878,0.009307946,0.0007436802,0.0004985621,0.000003324471,0.6985272,0.0006639416,0.004054639,0.05583986],"study_design_scores_gemma":[0.007870134,0.0002403986,0.1848001,0.0001267815,0.001344186,0.00001132985,0.00002879734,0.00915308,0.7925127,0.001849842,0.001639957,0.0004226771],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860017,0.006949103,0.00007068863,0.002004341,0.0002552396,0.001720752,0.00008299621,0.0002244438,0.002690688],"genre_scores_gemma":[0.9977646,0.0000477761,0.001405814,0.0002780234,0.0001370246,0.0001481112,0.00003995328,0.00002089294,0.0001577424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09398545,"threshold_uncertainty_score":0.5883453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08671062269174035,"score_gpt":0.3970710395602036,"score_spread":0.3103604168684632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}