{"id":"W2622233487","doi":"10.1039/c7sc01269a","title":"Multi-target-directed phenol–triazole ligands as therapeutic agents for Alzheimer's disease","year":2017,"lang":"en","type":"article","venue":"Chemical Science","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; Calgary Laboratory Services; Burnaby Hospital; Simon Fraser University; University of Calgary","funders":"Canada Research Chairs; National Institutes of Health; Alberta Prion Research Institute; Vetenskapsrådet; National Research Foundation of Korea; National Research Foundation; Alzheimer's Society; Canadian Institutes of Health Research; Alzheimer Society; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada; Michael Smith Health Research BC; National Institute on Aging; Alzheimer's Association","keywords":"Chemistry; Peptide; Combinatorial chemistry; Pharmacology; Toxicity; Triazole; Phenol; Biochemistry; Computational biology; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001593829,0.0002936423,0.0001756129,0.0001329686,0.0001138195,0.0001707974,0.0002003416,0.0003230651,0.002024699],"category_scores_gemma":[0.0001056396,0.00008716156,0.0001794547,0.000141007,0.0001536878,0.0002527416,0.0001593463,0.0003859302,0.0003454267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002245906,"about_ca_system_score_gemma":0.0002161216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005731672,"about_ca_topic_score_gemma":0.001529849,"domain_scores_codex":[0.9999441,0.000009796418,0.000003485992,0.00001058399,0.00001457923,0.00001754261],"domain_scores_gemma":[0.9999636,0.000007940168,0.00001142673,0.00000365405,0.000004977717,0.000008367824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000161853,0.00004500719,0.00009246781,0.00009148855,0.000008616938,0.0001870743,0.00002377904,0.0002562436,0.9913919,0.0005016202,0.000197655,0.007042199],"study_design_scores_gemma":[0.0000707116,0.001403945,0.001554954,0.00001333457,0.00003717788,0.001133134,0.00002656753,0.00197181,0.986094,0.000211403,0.007466198,0.00001669877],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9615861,0.01098386,0.01694332,0.0004722505,0.00009941339,0.0001033433,0.0002368213,0.0004179855,0.009156872],"genre_scores_gemma":[0.9898973,0.00287783,0.004275273,0.0001103177,0.00001684873,0.00002213199,0.0001127068,0.0000122912,0.0026753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002024699,"threshold_uncertainty_score":0.006773353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08671062269174035,"score_gpt":0.3970710395602036,"score_spread":0.3103604168684632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}