{"id":"W2622244301","doi":"10.1101/gr.211649.116","title":"Yeast genetic interaction screen of human genes associated with amyotrophic lateral sclerosis: identification of MAP2K5 kinase as a potential drug target","year":2017,"lang":"en","type":"article","venue":"Genome Research","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institute for Advanced Research; Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Precursory Research for Embryonic Science and Technology; National Human Genome Research Institute; Japan Science and Technology Agency; National Institutes of Health; National Research Foundation of Korea; Canada Excellence Research Chairs, Government of Canada; Japan Society for the Promotion of Science; Ministry of Education; Ministry of Science, ICT and Future Planning; National Research Foundation","keywords":"Biology; Gene; Zebrafish; Genetics; Amyotrophic lateral sclerosis; Optineurin; Yeast; Genetic screen; Mutation; Disease; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001752247,0.0004981342,0.0004751146,0.0004044742,0.0002235073,0.000201106,0.0002257314,0.0002149422,0.001022879],"category_scores_gemma":[0.0001485019,0.0001484361,0.0003957462,0.00046485,0.0001148389,0.00008420496,0.0002396572,0.0002586167,0.000335521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003487429,"about_ca_system_score_gemma":0.0003486646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001477774,"about_ca_topic_score_gemma":0.002302598,"domain_scores_codex":[0.9998491,0.00002480534,0.00001878023,0.00003502758,0.00005700043,0.00001527387],"domain_scores_gemma":[0.9999236,0.00002383508,0.00001581644,0.000008053438,0.00001069483,0.00001794396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001343291,0.00003478555,0.0007650523,0.00005269812,0.00002883988,0.0002881021,0.00001436754,0.0002670979,0.9964742,0.00007869103,0.0000897841,0.001772004],"study_design_scores_gemma":[0.00003493446,0.000395761,0.01351845,0.000006203826,0.0001504261,0.001343478,0.00005475643,0.004217302,0.9746824,0.00008464189,0.00549763,0.00001396537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795884,0.001800784,0.01261541,0.0001289464,0.00002171936,0.0001258303,0.004025599,0.0002729757,0.001420355],"genre_scores_gemma":[0.9766515,0.001094827,0.01491566,0.00007093096,0.000004307556,0.00008201162,0.005415928,0.00006095569,0.001703923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001477774,"threshold_uncertainty_score":0.003421843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07880199757103915,"score_gpt":0.3663631902972681,"score_spread":0.2875611927262289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}