{"id":"W2622244301","doi":"10.1101/gr.211649.116","title":"Yeast genetic interaction screen of human genes associated with amyotrophic lateral sclerosis: identification of MAP2K5 kinase as a potential drug target","year":2017,"lang":"en","type":"article","venue":"Genome Research","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institute for Advanced Research; Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Precursory Research for Embryonic Science and Technology; National Human Genome Research Institute; Japan Science and Technology Agency; National Institutes of Health; National Research Foundation of Korea; Canada Excellence Research Chairs, Government of Canada; Japan Society for the Promotion of Science; Ministry of Education; Ministry of Science, ICT and Future Planning; National Research Foundation","keywords":"Biology; Gene; Zebrafish; Genetics; Amyotrophic lateral sclerosis; Optineurin; Yeast; Genetic screen; Mutation; Disease; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001688347,0.0002194912,0.0005445876,0.0006025833,0.0006495712,0.0001802426,0.0007461368,0.000162744,0.0005164465],"category_scores_gemma":[0.0003610196,0.0001830406,0.0001534303,0.0003855687,0.000899564,0.0003016378,0.000438381,0.0006548957,0.0001134891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000315364,"about_ca_system_score_gemma":0.0003393106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002711428,"about_ca_topic_score_gemma":0.000115482,"domain_scores_codex":[0.9955096,0.0004674738,0.0007106148,0.0005643777,0.001987987,0.0007600011],"domain_scores_gemma":[0.996289,0.00004704852,0.0004995365,0.001264811,0.00159485,0.0003047443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007447902,0.0003873519,0.01774595,0.0001716878,0.0002751165,0.00008002446,0.0004538853,0.00007844808,0.9778187,0.00004331581,0.00007267022,0.002128079],"study_design_scores_gemma":[0.001856251,0.0009148187,0.9372112,0.0004661554,0.00006265172,0.00001954147,0.0001919628,0.000509961,0.05826903,0.000288969,0.00004565262,0.0001637792],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973665,0.0003282067,0.00004463971,0.0006568697,0.0000616906,0.0009930707,0.00008299784,0.00002974961,0.0004362917],"genre_scores_gemma":[0.9962516,0.0002635278,0.0002396362,0.000008835538,0.0002158414,0.00007975215,0.0001528268,0.00006519622,0.002722715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9195496,"threshold_uncertainty_score":0.746418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07880199757103915,"score_gpt":0.3663631902972681,"score_spread":0.2875611927262289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}