{"id":"W2622304925","doi":"10.1111/acel.12621","title":"Reprogramming progeria fibroblasts re‐establishes a normal epigenetic landscape","year":2017,"lang":"en","type":"article","venue":"Aging Cell","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; University of Toronto; University of Alberta; Ottawa Hospital; Hospital for Sick Children; University of Ottawa","funders":"Canadian Institutes of Health Research; Ontario Ministry of Research, Innovation and Science; Canada Research Chairs; Ontario Ministry of Research and Innovation; Ottawa Hospital Research Institute; Progeria Research Foundation","keywords":"Biology; Reprogramming; Epigenetics; Induced pluripotent stem cell; Progeria; Lamin; Nuclear lamina; Cell biology; LMNA; Genetics; Cancer research; Embryonic stem cell; Cell; Gene; Nuclear protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001067162,0.0001152233,0.00008749195,0.00001951915,0.0002966275,0.0001856786,0.00021995,0.00009357755,0.00005563343],"category_scores_gemma":[0.00004183991,0.0001087313,0.00006072443,0.00001989446,0.00004947649,0.000009672071,0.0001432845,0.00007643716,0.00003048618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003782238,"about_ca_system_score_gemma":0.00002252005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003030488,"about_ca_topic_score_gemma":0.00003514846,"domain_scores_codex":[0.9992388,0.0000178424,0.000110688,0.0003191442,0.00007890552,0.0002345769],"domain_scores_gemma":[0.9991325,0.000003670008,0.0001099962,0.0006565198,0.00003672237,0.00006060869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001004791,0.00005090742,0.08818395,0.00008888256,0.00004496896,0.00002214602,0.0002377427,0.00004478429,0.8585852,0.00001630896,0.01032947,0.04229512],"study_design_scores_gemma":[0.0008829577,0.0004321465,0.05562619,0.00004209274,0.00004405784,0.00003236493,0.000179928,0.0001478927,0.6738114,0.0001055287,0.2682276,0.0004677942],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982211,0.0003665871,0.0002766739,0.0001197284,0.0003498505,0.0001084181,0.000002152003,0.00002648634,0.01653908],"genre_scores_gemma":[0.9956995,0.00003874184,0.001710555,0.00007801274,0.0004641531,0.000006747621,0.00003766816,0.00002449113,0.001940126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2578982,"threshold_uncertainty_score":0.4433936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007085605795274941,"score_gpt":0.2288071662915101,"score_spread":0.2217215604962351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}