{"id":"W2622402732","doi":"10.1038/ncomms15652","title":"Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Direktör Albert Påhlssons Stiftelse; National Institute of Diabetes and Digestive and Kidney Diseases; Wallenberg Centre for Molecular and Translational Medicine; RWTH Aachen University; Vetenskapsrådet; Stiftelsen för Strategisk Forskning","keywords":"Gene knockdown; Regulator; Type 2 diabetes; Biology; Insulin; Beta cell; Islet; Phenotype; Cell biology; Internal medicine; Endocrinology; Secretion; Cell type; Insulin resistance; Chromatin; Gene; Cell; Diabetes mellitus; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001309342,0.0002700025,0.0002038825,0.000340719,0.0001304234,0.0003742633,0.0001368751,0.0002597571,0.001666528],"category_scores_gemma":[0.0001151414,0.000138654,0.0002839935,0.0002120919,0.0002215509,0.000123524,0.0002340916,0.0003130522,0.0002347924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001776277,"about_ca_system_score_gemma":0.00008237893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000459719,"about_ca_topic_score_gemma":0.0004882384,"domain_scores_codex":[0.9998868,0.00001501677,0.0000122135,0.00003133374,0.00003164042,0.0000231154],"domain_scores_gemma":[0.9998298,0.00001304958,0.00006818342,0.000009348289,0.00001149308,0.00006816497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004749455,0.00002958246,0.006758466,0.00003663527,0.00002749563,0.00031434,0.00003322523,0.000045996,0.9904184,0.00006905844,0.00009305182,0.001698825],"study_design_scores_gemma":[0.00009153347,0.0004806501,0.5338231,0.00004165089,0.0001404135,0.002692161,0.000326597,0.001677074,0.4551948,0.0002970259,0.005216908,0.00001810315],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975279,0.0007631633,0.0007728927,0.00004444268,0.00002009821,0.000003580719,0.0002960945,0.00003986005,0.0005318625],"genre_scores_gemma":[0.9981306,0.0002802034,0.0002475224,0.00004325597,0.000005771667,0.000005541735,0.0003712579,0.00001817283,0.0008976143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001666528,"threshold_uncertainty_score":0.005575061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02814047093759196,"score_gpt":0.3109100521095247,"score_spread":0.2827695811719327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}