{"id":"W2622451667","doi":"10.1158/1557-3265.ovcasymp16-ntoc-084","title":"Abstract NTOC-084: THE PROMISE OF COMBINATIONAL TREATMENT OF HISTONE DEACETYLASE 6 INHIBITOR ACY-1215 AND PROTEASOME INHIBITOR BORTEZOMIB IN SCCOHT","year":2017,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Bortezomib; Proteasome inhibitor; Proteasome; Cancer research; Biology; Histone deacetylase inhibitor; Cancer; Pharmacology; Histone deacetylase; Cell biology; Multiple myeloma; Immunology; Biochemistry; Histone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000212029,0.0004209655,0.0007603728,0.0003516373,0.0002080078,0.0004061156,0.0003904894,0.0003067919,0.002022567],"category_scores_gemma":[0.0001387615,0.0001337497,0.0005097324,0.0003230328,0.000178051,0.0003200782,0.0001938335,0.0009576853,0.0003357399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002988008,"about_ca_system_score_gemma":0.0004723654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006247843,"about_ca_topic_score_gemma":0.002641405,"domain_scores_codex":[0.9998723,0.00002732153,0.00001615105,0.00002309409,0.00003604641,0.00002502292],"domain_scores_gemma":[0.9999068,0.00001069889,0.00001971984,0.000009478492,0.0000181186,0.00003519236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.008508009,0.003752745,0.002142802,0.001704183,0.0002743344,0.000556448,0.00007502833,0.001354875,0.8805379,0.0003410137,0.00372589,0.09702684],"study_design_scores_gemma":[0.002867759,0.04802098,0.01746284,0.0001498938,0.00076584,0.002169788,0.0001803119,0.004771618,0.8881525,0.0002413404,0.03514801,0.00006909896],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9517921,0.03900739,0.002374124,0.0008131932,0.0004497051,0.000290667,0.0009076767,0.0002433538,0.004121902],"genre_scores_gemma":[0.9844595,0.008728541,0.002708382,0.0002208476,0.00009068668,0.0001236269,0.001057383,0.00002015449,0.002590844],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.002022567,"threshold_uncertainty_score":0.00676614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2455427028664833,"score_gpt":0.5711893694116348,"score_spread":0.3256466665451515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}