{"id":"W2622458078","doi":"10.1128/jvi.00634-17","title":"Comprehensive Cross-Clade Characterization of Antibody-Mediated Recognition, Complement-Mediated Lysis, and Cell-Mediated Cytotoxicity of HIV-1 Envelope-Specific Antibodies toward Eradication of the HIV-1 Reservoir","year":2017,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University of Toronto","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Antibody-dependent cell-mediated cytotoxicity; Antibody; Biology; Virology; Immune system; HIV vaccine; Immunology; Cytotoxicity; In vitro; Vaccine trial; Monoclonal antibody; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003474111,0.0004410164,0.0002712004,0.0002925673,0.0001052844,0.0002062322,0.0002586071,0.0002164947,0.0006238052],"category_scores_gemma":[0.0002479907,0.0001010411,0.0002488049,0.000194225,0.0001183152,0.0001519774,0.0001526511,0.0002927012,0.0001436327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002650703,"about_ca_system_score_gemma":0.0001579717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007983788,"about_ca_topic_score_gemma":0.000676319,"domain_scores_codex":[0.9998046,0.00005230316,0.00002378225,0.00002359177,0.00004956097,0.00004611747],"domain_scores_gemma":[0.9998837,0.00003779721,0.00001788925,0.00001676646,0.00003060634,0.00001325725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001177189,0.00008164875,0.0003064824,0.00003664777,0.000009348412,0.00001779217,0.00001003119,0.0002289108,0.9969968,0.0000350157,0.00001262633,0.002147105],"study_design_scores_gemma":[0.00001639159,0.0007994689,0.003413473,0.000004239675,0.00002649967,0.0001350822,0.000005920356,0.0008970891,0.994087,0.00002042308,0.0005921232,0.000002342894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950421,0.001146242,0.002703835,0.00001551783,0.000005428583,0.00006689562,0.0002513907,0.00002175801,0.0007467969],"genre_scores_gemma":[0.9957846,0.000569327,0.002041197,0.00003465248,0.000005354298,0.00004035337,0.0007962443,0.000008718343,0.0007196158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007983788,"threshold_uncertainty_score":0.002086818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03878214109531176,"score_gpt":0.3026011642355101,"score_spread":0.2638190231401983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}