{"id":"W2622461305","doi":"10.1016/j.biopsych.2017.05.024","title":"Somatostatin-Positive Gamma-Aminobutyric Acid Interneuron Deficits in Depression: Cortical Microcircuit and Therapeutic Perspectives","year":2017,"lang":"en","type":"review","venue":"Biological Psychiatry","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":345,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Institute of Mental Health","keywords":"Neuroscience; GABAergic; Glutamatergic; Interneuron; Inhibitory postsynaptic potential; gamma-Aminobutyric acid; Excitatory postsynaptic potential; Psychology; Biology; Mood disorders; Glutamate receptor; Anxiety; Psychiatry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003392593,0.0006413769,0.001367946,0.0003276812,0.0005107307,0.0001927973,0.00133657,0.0005128687,0.00006452876],"category_scores_gemma":[0.0008901705,0.0004246164,0.0003294729,0.0003661469,0.00150792,0.0001219908,0.0006131904,0.001942554,0.000133067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006404055,"about_ca_system_score_gemma":0.000274505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002573559,"about_ca_topic_score_gemma":0.000001973857,"domain_scores_codex":[0.994329,0.001808892,0.0006534324,0.002007614,0.0003171822,0.0008839151],"domain_scores_gemma":[0.9975922,0.001190562,0.0003925129,0.0005400001,0.00002370767,0.0002610871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002914091,0.001595855,0.00842844,0.001910954,0.00004434769,0.001412241,0.0003030234,1.094708e-7,0.04929632,0.002103062,0.0002190149,0.9343953],"study_design_scores_gemma":[0.007358687,0.009206195,0.05983012,0.01795179,0.001259722,0.01315171,0.0009586012,0.000136008,0.01414794,0.004031818,0.8636022,0.008365219],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.06493261,0.9321163,0.000005997264,0.0001354272,0.000965534,0.001117104,0.00006579233,0.0000819741,0.0005793146],"genre_scores_gemma":[0.1262688,0.8727223,0.00001346289,0.0005514391,0.0001562643,0.0001230588,0.000002389776,0.00004259053,0.0001196769],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.92603,"threshold_uncertainty_score":0.9998206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2060018875601109,"score_gpt":0.4366839046812649,"score_spread":0.2306820171211541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}