{"id":"W2622523903","doi":"10.1093/neuonc/nox109","title":"Phase I study of oral sonidegib (LDE225) in pediatric brain and solid tumors and a phase II study in children and adults with relapsed medulloblastoma","year":2017,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":174,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Novartis Pharmaceuticals Corporation","keywords":"Medicine; Smoothened; Medulloblastoma; Internal medicine; Pharmacokinetics; Oncology; Adverse effect; Hedgehog; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004615128,0.000260425,0.000579095,0.0001775392,0.0002009797,0.00002235378,0.0001960062,0.0001332423,0.000001075259],"category_scores_gemma":[0.0005012674,0.0002311716,0.00001937868,0.00009984049,0.0002716446,0.00001266111,0.0004969678,0.0002314992,2.180901e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001551804,"about_ca_system_score_gemma":0.000117373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002586685,"about_ca_topic_score_gemma":0.004327946,"domain_scores_codex":[0.9981241,0.0003053908,0.0004118109,0.0007111062,0.0001277983,0.0003198204],"domain_scores_gemma":[0.9990695,0.00008078507,0.0002911354,0.0003900209,0.00005689982,0.0001117274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003897412,0.01016398,0.84394,0.00003217916,0.000103462,0.0003837036,0.008441089,0.000008827534,0.1207224,0.000001272168,0.0001005994,0.01220502],"study_design_scores_gemma":[0.1171592,0.1738782,0.6924658,0.00003463337,0.0001774037,0.0002404986,0.005490831,0.0001086604,0.009788914,0.00001010475,0.0001284362,0.0005172999],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980866,0.0002971467,0.000001971103,0.0002023739,0.00004731875,0.001309089,0.00001759206,0.000008748373,0.00002919065],"genre_scores_gemma":[0.9995369,0.0001335688,0.00005063645,0.00009142922,0.00006355632,0.0000823628,0.000006808967,0.00002777195,0.000006968475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1637142,"threshold_uncertainty_score":0.9426904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01336037195266052,"score_gpt":0.3147277899684112,"score_spread":0.3013674180157507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}