{"id":"W2622523903","doi":"10.1093/neuonc/nox109","title":"Phase I study of oral sonidegib (LDE225) in pediatric brain and solid tumors and a phase II study in children and adults with relapsed medulloblastoma","year":2017,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":174,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Novartis Pharmaceuticals Corporation","keywords":"Medicine; Smoothened; Medulloblastoma; Internal medicine; Pharmacokinetics; Oncology; Adverse effect; Hedgehog; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009701526,0.0008432089,0.001135087,0.000227794,0.0002101156,0.0003706098,0.0004006776,0.0004759205,0.001841897],"category_scores_gemma":[0.0006102592,0.0003088856,0.0006877066,0.0002312977,0.0004968122,0.0003021553,0.0002452974,0.001426428,0.0003693228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008431342,"about_ca_system_score_gemma":0.001883838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001163376,"about_ca_topic_score_gemma":0.003125851,"domain_scores_codex":[0.9996897,0.00013629,0.00002274339,0.00005575828,0.00004513028,0.00005030831],"domain_scores_gemma":[0.9994307,0.00007184307,0.0001343512,0.00004241641,0.00004972999,0.0002709714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4853612,0.06280623,0.07844178,0.001100074,0.002187202,0.001278825,0.0007267172,0.005231867,0.142476,0.0006105098,0.00674661,0.213033],"study_design_scores_gemma":[0.2489477,0.625164,0.08782035,0.00007804701,0.000827806,0.002356625,0.0001618295,0.003221626,0.02233586,0.0002757234,0.008771733,0.00003879551],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963205,0.0007964715,0.0004600892,0.0001411639,0.00001557994,0.001072734,0.0006282108,0.00003882757,0.0005265613],"genre_scores_gemma":[0.9883986,0.001419419,0.003411646,0.0004306883,0.00005523018,0.002558402,0.002533886,0.00002831998,0.001163816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001841897,"threshold_uncertainty_score":0.006161749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01336037195266052,"score_gpt":0.3147277899684112,"score_spread":0.3013674180157507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}