{"id":"W2622682706","doi":"10.1101/147611","title":"Network Connectivity Determines Cortical Thinning In Early Parkinson’s Disease Progression","year":2017,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Sanofi Genzyme; Genentech; H. Lundbeck A/S; Teva Pharmaceutical Industries; Biogen; GlaxoSmithKline; Eli Lilly and Company; Bristol-Myers Squibb; Servier; Pfizer; Sanofi; Alzheimer's Association; Natural Sciences and Engineering Research Council of Canada; W. Garfield Weston Foundation; Michael J. Fox Foundation for Parkinson's Research","keywords":"Atrophy; Brainstem; Cerebral cortex; Cortex (anatomy); Cognition; Frontal cortex; Cognitive decline; Frontal lobe; Degenerative disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003992045,0.0001932211,0.0002491679,0.0007891727,0.0002110192,0.0004155855,0.0001453321,0.0002397909,0.001385777],"category_scores_gemma":[0.001765659,0.000157065,0.0001476431,0.0003964308,0.000264799,0.0004308774,0.000260185,0.0002979439,0.0001245221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002491306,"about_ca_system_score_gemma":0.0001298633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002391472,"about_ca_topic_score_gemma":0.004288662,"domain_scores_codex":[0.9999076,0.00002636163,0.000007746514,0.00002635705,0.00001658749,0.00001534906],"domain_scores_gemma":[0.999258,0.0002043465,0.0003181206,0.00004631111,0.00009136203,0.00008177668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001413701,0.0001292197,0.9489725,0.00005553029,0.0001634425,0.0008307613,0.0004258277,0.001371806,0.03212679,0.0002353289,0.0004359812,0.01383901],"study_design_scores_gemma":[0.000004219586,0.00006147303,0.9976614,0.000004983816,0.00001418716,0.0003281776,0.00005313212,0.0006926033,0.0009066577,0.0001805933,0.00009012,0.000002514929],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989787,0.00015823,0.0002780196,0.00002775175,0.000001449337,0.000005223198,0.0001938424,0.000006233852,0.0003505753],"genre_scores_gemma":[0.9995203,0.00006605643,0.0001389104,0.000005264165,0.000002134218,0.000003873387,0.0001623113,0.000001808687,0.00009942608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002391472,"threshold_uncertainty_score":0.00475508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02305843023801834,"score_gpt":0.2721608615702361,"score_spread":0.2491024313322178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}