{"id":"W2622688675","doi":"10.1128/aac.02114-16","title":"PA3225 Is a Transcriptional Repressor of Antibiotic Resistance Mechanisms in Pseudomonas aeruginosa","year":2017,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research; Cystic Fibrosis Canada; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Biofilm; Pseudomonas aeruginosa; Biology; Microbiology; Repressor; Efflux; Mutant; Gene; Wild type; Transcriptional regulation; Transcriptome; Operon; ATP-binding cassette transporter; Genetics; Gene expression; Bacteria; Transporter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001468714,0.000650451,0.0004708666,0.000358395,0.0002690761,0.0003256174,0.0003082522,0.0003433758,0.001442248],"category_scores_gemma":[0.0003104675,0.0002497156,0.0003902388,0.0002621081,0.0003134786,0.0001442621,0.000437961,0.000573437,0.001480965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000410753,"about_ca_system_score_gemma":0.0003247651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001155923,"about_ca_topic_score_gemma":0.0009036086,"domain_scores_codex":[0.9997709,0.00003067673,0.00001553663,0.00006074589,0.00008965657,0.00003253733],"domain_scores_gemma":[0.9997745,0.00004058122,0.00007043406,0.00002858245,0.00002741224,0.00005852681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004563596,0.00001832734,0.0002157234,0.00001652415,0.000002578942,0.0001213147,0.000007338068,0.00005761564,0.9988958,0.00004148708,0.00005278222,0.0005247563],"study_design_scores_gemma":[0.00004488119,0.0003563993,0.03526632,0.00002871372,0.00002449301,0.001649555,0.0001302096,0.006356222,0.9495824,0.0003019517,0.006216475,0.00004247289],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936253,0.001014373,0.003450721,0.0001341317,0.00003163864,0.00002606838,0.0007144313,0.0002037488,0.0007996026],"genre_scores_gemma":[0.994021,0.0001812884,0.002175061,0.00008618234,0.00001046085,0.00003824507,0.001532247,0.00006011553,0.001895417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001442248,"threshold_uncertainty_score":0.004824817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01214262054374367,"score_gpt":0.2593895966406096,"score_spread":0.2472469760968659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}