{"id":"W2622706150","doi":"10.1200/jco.2017.35.15_suppl.1084","title":"A phase 2 study of napabucasin with weekly paclitaxel in previously treated metastatic breast cancer.","year":2017,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"St Mary's Hospital Centre","funders":"","keywords":"Medicine; Metastatic breast cancer; Breast cancer; Paclitaxel; Internal medicine; Taxane; Cancer; Oncology; Adverse effect; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001004986,0.001470526,0.001853641,0.0007106605,0.0004665404,0.0007837269,0.001097669,0.001266913,0.004770928],"category_scores_gemma":[0.0005808306,0.0006909424,0.00101265,0.0004895908,0.0006811539,0.0007784071,0.0003698446,0.002843337,0.001230358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001011748,"about_ca_system_score_gemma":0.001609911,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001940655,"about_ca_topic_score_gemma":0.004314698,"domain_scores_codex":[0.9997546,0.00008034355,0.00001293684,0.00005371107,0.00003130018,0.00006695386],"domain_scores_gemma":[0.9995808,0.0000491595,0.00006823429,0.00004644582,0.00003217441,0.0002231837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5144444,0.2518305,0.005226794,0.0008809732,0.001176312,0.000541975,0.0004343748,0.002570235,0.09786228,0.0002980982,0.004255871,0.1204783],"study_design_scores_gemma":[0.3770029,0.6016399,0.009707127,0.00003587803,0.0003721722,0.0004588128,0.0000633505,0.001253878,0.005824807,0.0001372303,0.003476732,0.00002730074],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913828,0.001334563,0.0005126754,0.0003369327,0.0001394704,0.003648937,0.0007585813,0.0001047337,0.001781374],"genre_scores_gemma":[0.9796839,0.002585125,0.002402116,0.0008453777,0.0002520398,0.005381879,0.002865823,0.00005949657,0.00592423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004770928,"threshold_uncertainty_score":0.0159604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.438716383470474,"score_gpt":0.6221150318501938,"score_spread":0.1833986483797198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}