{"id":"W2622918134","doi":"10.1182/blood.v128.22.5083.5083","title":"Lef1 Is a Critical Mediator of Wnt/β-Catenin Signaling in T-Cell Acute Lymphoblastic Leukemia (T-ALL)","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"T-cell and Retrovirus Studies","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Wnt signaling pathway; Leukemia; Cancer research; Biology; Population; LRP6; Beta-catenin; WNT3A; Immunology; Signal transduction; Cell biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001341797,0.0001839285,0.0003808126,0.0001139673,0.00006391628,0.00000415201,0.0002004608,0.0002543989,0.0002968681],"category_scores_gemma":[0.0001380793,0.0001175155,0.0001077962,0.0001002454,0.0003724603,0.00005048864,0.0001234634,0.0001349644,0.0005515392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004680093,"about_ca_system_score_gemma":0.000116245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008181481,"about_ca_topic_score_gemma":0.00001501451,"domain_scores_codex":[0.9987562,0.00008905472,0.0003658285,0.000295851,0.00004830055,0.0004447427],"domain_scores_gemma":[0.9992025,0.0004833413,0.00007745042,0.0001477431,0.00005818719,0.00003073063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008400779,0.000322893,0.005307321,0.00003829307,0.0002348332,0.00002769823,0.0003881721,1.694539e-7,0.9920569,0.0003860866,0.0008743436,0.0002792619],"study_design_scores_gemma":[0.004566762,0.000233079,0.0007168158,0.00009157752,0.000234081,0.00003204472,0.0001640691,3.46867e-7,0.9927829,0.0001610095,0.0008353547,0.0001819428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942803,0.003829731,0.00004252453,0.0003080074,0.000323653,0.0000951478,0.00006935664,0.00003963047,0.001011684],"genre_scores_gemma":[0.9977332,0.000315959,0.0000789254,0.0001195835,0.00004223913,0.00001679086,0.000004992477,0.00001788915,0.001670464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004590506,"threshold_uncertainty_score":0.7089104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009876881711327822,"score_gpt":0.2274177365811152,"score_spread":0.2175408548697874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}