{"id":"W2623017876","doi":"10.1093/nar/gkx517","title":"New insights into a classic aptamer: binding sites, cooperativity and more sensitive adenosine detection","year":2017,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":165,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Aptamer; Cooperativity; Isothermal titration calorimetry; Biology; Cooperative binding; Biosensor; Binding site; Adenosine; Biophysics; Adenosine triphosphate; DNA; Biochemistry; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003774699,0.0001692472,0.0001909692,0.000146864,0.001120545,0.0002203007,0.0002179859,0.0002444338,0.00000224272],"category_scores_gemma":[0.0004685045,0.0001423853,0.00005890902,0.0001545577,0.0005445053,0.00002279775,0.0004512035,0.000350023,0.000009394123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005168128,"about_ca_system_score_gemma":0.00008112342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002101803,"about_ca_topic_score_gemma":0.0005821703,"domain_scores_codex":[0.9985285,0.0001542554,0.0001461607,0.0005452329,0.0003040831,0.0003217513],"domain_scores_gemma":[0.9987996,0.00002557928,0.00008121607,0.0006322013,0.0003051893,0.0001562531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009297413,0.00002171249,0.0008692514,0.000008997271,0.00004270675,0.00001467418,0.0001150697,2.708325e-7,0.9252747,0.00002170154,0.0008037422,0.07273423],"study_design_scores_gemma":[0.0003132348,0.0003660884,0.004449351,0.00003213953,0.00001491878,0.00002001728,0.0002032856,0.0004218467,0.9820234,0.0001176471,0.01184363,0.0001944506],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942459,0.0002668349,0.003960281,0.0007002978,0.00003277986,0.0001883574,0.000004496349,0.00003634169,0.0005646874],"genre_scores_gemma":[0.992995,0.0006212951,0.004530175,0.00005240061,0.000308712,0.000005445632,0.00003269113,0.00002478645,0.001429555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07253978,"threshold_uncertainty_score":0.8618442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03285391327941634,"score_gpt":0.3568020309722608,"score_spread":0.3239481176928444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}