{"id":"W2623056867","doi":"10.1186/s13229-017-0137-9","title":"Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia","year":2017,"lang":"en","type":"review","venue":"Molecular Autism","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":645,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles; David Geffen School of Medicine, University of California, Los Angeles; National Institute of Mental Health; Statens Serum Institut; Canadian Institutes of Health Research; Roy J. and Lucille A. Carver College of Medicine, University of Iowa; Department of Psychiatry, University of Toronto; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai; Stanley Center for Psychiatric Research, Broad Institute; Research Institute, Nationwide Children's Hospital; University of North Carolina at Chapel Hill; University of Washington; University of California, Los Angeles; University of Illinois at Urbana-Champaign; Health Research Board; Hospital for Sick Children; H. Lundbeck A/S; Università di Bologna; Yale University; Karolinska Institutet; Centers for Disease Control and Prevention; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Institut National de la Santé et de la Recherche Médicale; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai; Trinity College Dublin; Newcastle University; McMaster University; Université de Toulouse; Ukrainian Research Institute, Harvard University; University of Oxford; University of Toronto; University of Alberta; Broad Institute; Deutsches Krebsforschungszentrum; University College Dublin; McGill University; Johns Hopkins University; Rush University; Weill Cornell Medical College; Aarhus Universitetshospital; Aarhus Universitet; Massachusetts General Hospital; University of Minnesota; Region Hovedstaden; University of Pennsylvania; Johns Hopkins Bloomberg School of Public Health; University of Miami; Universidade de Coimbra; Vanderbilt University; National Cancer Institute; Lundbeckfonden; Cardiff University; Genome Canada; Brown University; Wellcome Trust; Medical Research Council; Battelle; University of Southern California; School of Medicine, Indiana University; University of Pittsburgh; Nationwide Children's Hospital; Carnegie Mellon University; Autism Speaks","keywords":"Schizophrenia spectrum; Genome-wide association study; Autism spectrum disorder; Autism; Schizophrenia (object-oriented programming); Neuropsychology; Psychology; Psychiatry; Neurology; Clinical psychology; Medicine; Psychosis; Genetics; Single-nucleotide polymorphism; Cognition; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00344455,0.001105909,0.003079211,0.002913577,0.0002317854,0.001283373,0.001132241,0.001010004,0.001715601],"category_scores_gemma":[0.004406704,0.000399998,0.003265769,0.003739951,0.0003082182,0.0005345849,0.0007910621,0.001281471,0.0002767319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008364469,"about_ca_system_score_gemma":0.002010608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003022634,"about_ca_topic_score_gemma":0.008525003,"domain_scores_codex":[0.9989346,0.000357153,0.0001733797,0.0002507547,0.0002306303,0.00005350267],"domain_scores_gemma":[0.9976984,0.001549956,0.0003446882,0.00009246068,0.0002351834,0.00007935364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001262474,0.00004642834,0.02882565,0.07554413,0.06827778,0.001390863,0.0001733871,0.001548206,0.001967863,0.003298605,0.02439016,0.7932746],"study_design_scores_gemma":[0.0006709986,0.000700494,0.1930522,0.04865475,0.2874493,0.011007,0.0004302889,0.001735818,0.003428703,0.01593819,0.4366307,0.0003014645],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.0008320783,0.997923,0.0003598298,0.0004144126,0.00009337534,0.000004965092,0.0001049167,0.00001169218,0.0002557903],"genre_scores_gemma":[0.01786475,0.9801607,0.0008037974,0.0004044753,0.0002328488,0.00001913156,0.0002823914,0.000009236536,0.0002226791],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.00344455,"threshold_uncertainty_score":0.01821673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04460943152096091,"score_gpt":0.3026112739105564,"score_spread":0.2580018423895954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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