{"id":"W2623101650","doi":"10.2337/db16-1403","title":"The SNARE Protein Syntaxin-1a Plays an Essential Role in Biphasic Exocytosis of the Incretin Hormone Glucagon-Like Peptide 1","year":2017,"lang":"en","type":"article","venue":"Diabetes","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Banting and Best Diabetes Centre, University of Toronto; University of Toronto; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Wellcome Trust; Medical Research Council; Wellcome","keywords":"Exocytosis; Incretin; Glucagon-like peptide-1; Syntaxin; Hormone; Glucagon; Cell biology; Internal medicine; Chemistry; Endocrinology; Medicine; Biology; Secretion; Type 2 diabetes; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002330612,0.000408693,0.0002968982,0.0002709285,0.0001859387,0.000421918,0.0002095666,0.0004188476,0.0005708781],"category_scores_gemma":[0.0002358579,0.0002365608,0.0003218505,0.000108857,0.0003071346,0.0004197213,0.0003840705,0.0004478451,0.0002539229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003213247,"about_ca_system_score_gemma":0.0001944755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003439613,"about_ca_topic_score_gemma":0.0003177195,"domain_scores_codex":[0.9998122,0.00003580298,0.00002569385,0.00003873542,0.00004534718,0.00004225597],"domain_scores_gemma":[0.9998072,0.00002671623,0.00006785063,0.00001412912,0.00002124267,0.00006301038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001469684,0.000008160066,0.0002801441,0.00002131188,0.000003769017,0.00007196287,0.000008144058,0.00004040013,0.998838,0.00006703942,0.00001928573,0.0004948354],"study_design_scores_gemma":[0.0000551907,0.0004038191,0.03827208,0.00002743407,0.00004105968,0.00111949,0.0000778203,0.00299071,0.9545317,0.0002158972,0.002247824,0.00001684548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940857,0.001624226,0.003408256,0.0001286488,0.0000190844,0.00001517462,0.0002234147,0.00006405763,0.0004314467],"genre_scores_gemma":[0.9972625,0.000707895,0.001176138,0.00004000598,0.000007212599,0.00001548678,0.0001688105,0.00001466815,0.0006072882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005708781,"threshold_uncertainty_score":0.002331436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005877172768040033,"score_gpt":0.2124507743069065,"score_spread":0.2065736015388664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}