{"id":"W2623101650","doi":"10.2337/db16-1403","title":"The SNARE Protein Syntaxin-1a Plays an Essential Role in Biphasic Exocytosis of the Incretin Hormone Glucagon-Like Peptide 1","year":2017,"lang":"en","type":"article","venue":"Diabetes","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Banting and Best Diabetes Centre, University of Toronto; University of Toronto; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Wellcome Trust; Medical Research Council; Wellcome","keywords":"Exocytosis; Incretin; Glucagon-like peptide-1; Syntaxin; Hormone; Glucagon; Cell biology; Internal medicine; Chemistry; Endocrinology; Medicine; Biology; Secretion; Type 2 diabetes; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002752126,0.0001349384,0.0001359344,0.00001971322,0.0003350414,0.0000585903,0.0005681139,0.0001268325,0.000009698477],"category_scores_gemma":[0.00005674611,0.00009013293,0.00011017,0.0000410707,0.0002256425,0.000009549824,0.0001121911,0.0001076044,0.000002903693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008052982,"about_ca_system_score_gemma":0.0000441088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001488827,"about_ca_topic_score_gemma":0.0004401678,"domain_scores_codex":[0.9990929,0.00007190117,0.0002038047,0.0002397128,0.0001434411,0.0002481872],"domain_scores_gemma":[0.9989807,0.00000998496,0.0001631027,0.0007585488,0.00004501556,0.000042646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006322566,0.00003235177,0.05003858,0.00001316879,0.00002272059,7.509601e-7,0.00009661823,0.000005968287,0.9490606,0.00003847472,0.00001789212,0.0006096232],"study_design_scores_gemma":[0.0003756807,0.000138024,0.1064719,0.00003376783,0.00001804016,3.711723e-7,0.0001164965,0.0001241542,0.889293,0.000111412,0.003189225,0.0001279364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980116,0.001093352,0.00002632879,0.0001664428,0.00008180476,0.0003068808,0.00002749095,0.000005490502,0.0002805821],"genre_scores_gemma":[0.999171,0.00009076941,0.00003110908,0.00002352545,0.0001098065,0.00005613918,0.0003017764,0.00001830926,0.0001975923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05976768,"threshold_uncertainty_score":0.3675514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005877172768040033,"score_gpt":0.2124507743069065,"score_spread":0.2065736015388664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}