{"id":"W2623210482","doi":"10.1016/j.str.2017.05.013","title":"RBR Ubiquitin Transfer: Not Simply an “Open” and “Closed” Case?","year":2017,"lang":"en","type":"letter","venue":"Structure","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Ubiquitin; Chemistry; Computational biology; Cell biology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0001353882,0.0005473983,0.0004615546,0.00005195421,0.0004173797,0.0003989106,0.0009890785,0.0018345,0.0002552423],"category_scores_gemma":[0.00004453873,0.000493922,0.0001063909,0.00002587206,0.0002243627,0.0000126309,0.0003370226,0.001155614,0.000005814966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001254172,"about_ca_system_score_gemma":0.0001568898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000187847,"about_ca_topic_score_gemma":0.0003759068,"domain_scores_codex":[0.9978647,0.0001597964,0.0002604407,0.0009988503,0.0001969465,0.0005192381],"domain_scores_gemma":[0.9983293,0.00001368895,0.0001238207,0.001291516,0.00008882539,0.0001527955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001634037,0.00001659307,0.00009188095,0.0004485209,0.0002144547,0.005872081,0.0002672761,7.619375e-7,0.2887469,0.0001078444,0.686743,0.01732731],"study_design_scores_gemma":[0.0006017656,0.0004402648,0.0001063015,0.00003470031,0.00007345665,0.004229445,0.00002365414,0.000001844415,0.1553027,0.0006233454,0.8379164,0.0006461034],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8658779,0.001098654,0.0000675458,0.1142099,0.00104995,0.00177005,0.009081531,0.00006678396,0.006777655],"genre_scores_gemma":[0.6952711,0.0001117395,0.0005385385,0.2879808,0.008279284,0.00004964166,0.004573278,0.0001661808,0.003029357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1737709,"threshold_uncertainty_score":0.9997513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02283580435037525,"score_gpt":0.2796820589585753,"score_spread":0.2568462546082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}