{"id":"W2623263876","doi":"10.1158/2159-8290.cd-17-0419","title":"Secondary Somatic Mutations Restoring <i>RAD51C</i> and <i>RAD51D</i> Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma","year":2017,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":417,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; BC Cancer Agency","funders":"National Institute of Environmental Health Sciences; National Cancer Institute; National Institute of General Medical Sciences; Cancer Research UK","keywords":"Cancer research; PARP inhibitor; Germline mutation; Biology; Olaparib; Mutation; Medicine; Genetics; Gene; Poly ADP ribose polymerase; Polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003365617,0.000301475,0.0004984154,0.0001236893,0.0006373344,0.0003075854,0.0002881013,0.0001142705,0.00004657413],"category_scores_gemma":[0.000164466,0.0002299997,0.0000663863,0.0002512242,0.0003427292,0.0007408127,0.0000896393,0.0003075131,0.000006564567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007709692,"about_ca_system_score_gemma":0.000744751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008509278,"about_ca_topic_score_gemma":0.008837909,"domain_scores_codex":[0.9979726,0.0001051143,0.0004280268,0.000558418,0.0004508699,0.0004849767],"domain_scores_gemma":[0.9982985,0.0001851209,0.0003466656,0.0008855669,0.00008295693,0.0002012311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002780089,0.0004678702,0.9278662,0.0005917272,0.0005615443,0.0003755929,0.008486041,0.0006873509,0.02768918,0.003430985,0.02482936,0.002234087],"study_design_scores_gemma":[0.007243521,0.000177793,0.9713956,0.002036946,0.0001592157,0.00002035807,0.000464333,0.00006109697,0.011943,0.0009909102,0.005070318,0.0004369675],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9785051,0.001589546,0.000133726,0.01638944,0.0006201538,0.0009476041,0.0002634716,0.00006098675,0.001489958],"genre_scores_gemma":[0.9941635,0.0001356488,0.0003425545,0.001900051,0.0005467574,0.0006697426,0.00004269572,0.00006523703,0.002133803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04352937,"threshold_uncertainty_score":0.9379116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02426957560772021,"score_gpt":0.284101260368508,"score_spread":0.2598316847607878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}