{"id":"W2623319650","doi":"10.1016/j.mod.2017.04.358","title":"Directing Stem Cell Fate by Altering Metabolites","year":2017,"lang":"en","type":"article","venue":"Mechanisms of Development","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Regenerative Medicine; Children’s Health Research Institute; Hospital for Sick Children; Western University","funders":"","keywords":"Biology; Stem cell; Cell biology; Cell fate determination; Computational biology; Genetics; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002908904,0.0003402475,0.000170605,0.0003518566,0.000185882,0.0007690466,0.0003604617,0.0003348384,0.002105656],"category_scores_gemma":[0.0002105034,0.0001451397,0.0001903511,0.0002453798,0.0003284612,0.000563983,0.0003149624,0.0004221198,0.0004499496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004137085,"about_ca_system_score_gemma":0.0003624973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003749171,"about_ca_topic_score_gemma":0.0006382789,"domain_scores_codex":[0.9998804,0.00003301049,0.00001022459,0.00002611609,0.00002603333,0.00002415152],"domain_scores_gemma":[0.9998661,0.00002927746,0.00004461871,0.00001780468,0.00001821697,0.00002390925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002318323,0.00003971255,0.0003985571,0.00008990826,0.000009672365,0.0001078171,0.00003009098,0.0003073157,0.9825552,0.005795938,0.0001507548,0.01028312],"study_design_scores_gemma":[0.00001343414,0.0001805036,0.0005221149,0.000008244926,0.00001443687,0.0000924846,0.00002353701,0.0002968057,0.9898779,0.0008619329,0.00810326,0.000005472849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9039667,0.0171956,0.04940985,0.002359282,0.000344475,0.0001619969,0.001007575,0.0005697761,0.02498473],"genre_scores_gemma":[0.983876,0.00463269,0.007221392,0.0001489913,0.00002321984,0.00002284409,0.000134089,0.00004917763,0.003891568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002105656,"threshold_uncertainty_score":0.007044137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01497572514325515,"score_gpt":0.2432289220703661,"score_spread":0.2282531969271109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}