{"id":"W2623352127","doi":"10.1016/j.stemcr.2017.05.017","title":"A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response","year":2017,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":636,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University; Memorial University of Newfoundland","funders":"Wellcome; Royal Society; Innovative Medicines Initiative; Oxford Martin School, University of Oxford; Alzheimer’s Research UK; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Parkinson's UK; National Institute for Health and Care Research; Wellcome Trust; Alzheimer's Research Trust; Medical Research Council; Kennedy Trust for Rheumatology Research; Seventh Framework Programme; European Federation of Pharmaceutical Industries and Associations","keywords":"Microglia; Biology; Induced pluripotent stem cell; Neuroinflammation; Neuroscience; Cell biology; Cellular differentiation; Embryonic stem cell; Immunology; Inflammation; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003474329,0.0004636346,0.0003119216,0.0004051223,0.0001969453,0.0003468379,0.0002326531,0.0004389731,0.001566441],"category_scores_gemma":[0.0001776337,0.000163533,0.0002698422,0.0002271889,0.0002333976,0.0002896736,0.0003089958,0.0007269311,0.0006356791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000167538,"about_ca_system_score_gemma":0.0002085072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002823368,"about_ca_topic_score_gemma":0.0005179844,"domain_scores_codex":[0.9996761,0.00004875991,0.00005063276,0.00005463664,0.0001349321,0.00003501991],"domain_scores_gemma":[0.9998649,0.00002020043,0.00003717959,0.0000303297,0.000027633,0.00001967589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007892842,0.00004660558,0.0002564153,0.00007852321,0.00001001453,0.0001633873,0.00005394846,0.0003016911,0.9943748,0.0006334137,0.0002412031,0.003761202],"study_design_scores_gemma":[0.00002034645,0.0003203107,0.001505446,0.0000238311,0.00004618035,0.0007596841,0.0000425209,0.002136462,0.9830205,0.0003376203,0.01177487,0.00001217684],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8993651,0.004242283,0.0819779,0.0004626747,0.0002509413,0.0004196649,0.003507099,0.0006733823,0.009100975],"genre_scores_gemma":[0.9539291,0.00232836,0.03368657,0.0001374095,0.00003993826,0.0005339042,0.002487696,0.00009556754,0.006761512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001566441,"threshold_uncertainty_score":0.005240262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02733445802074041,"score_gpt":0.2524441199689575,"score_spread":0.2251096619482171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}