{"id":"W2623352127","doi":"10.1016/j.stemcr.2017.05.017","title":"A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response","year":2017,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":636,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University; Memorial University of Newfoundland","funders":"Wellcome; Royal Society; Innovative Medicines Initiative; Oxford Martin School, University of Oxford; Alzheimer’s Research UK; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Parkinson's UK; National Institute for Health and Care Research; Wellcome Trust; Alzheimer's Research Trust; Medical Research Council; Kennedy Trust for Rheumatology Research; Seventh Framework Programme; European Federation of Pharmaceutical Industries and Associations","keywords":"Microglia; Biology; Induced pluripotent stem cell; Neuroinflammation; Neuroscience; Cell biology; Cellular differentiation; Embryonic stem cell; Immunology; Inflammation; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.0006262815,0.0004676797,0.000356628,0.0001782165,0.001948097,0.0006579229,0.0004168221,0.0001572055,0.00003117084],"category_scores_gemma":[0.00003431234,0.0004129387,0.0001507613,0.00007761687,0.0001842498,0.0003576133,0.0003461383,0.0003654266,0.00007373426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000672578,"about_ca_system_score_gemma":0.0001093159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001184783,"about_ca_topic_score_gemma":7.86225e-7,"domain_scores_codex":[0.9958209,0.0004212424,0.0009297924,0.001445591,0.0008606767,0.0005217454],"domain_scores_gemma":[0.9965194,0.00008296603,0.00123516,0.001702363,0.00009851187,0.0003615772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002315767,0.0001330205,0.00004510132,0.00007873456,9.915591e-7,0.001265705,0.0008938629,0.001425627,0.9943218,0.0002454036,0.001247631,0.0001106031],"study_design_scores_gemma":[0.0006336498,0.0001442423,0.0003977817,0.00004977203,0.000009901662,0.0002276391,0.00005765508,0.005225644,0.9874729,0.00004924223,0.00531556,0.0004160243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936865,0.0000627984,0.0004573787,0.0001030249,0.0006994437,0.001141572,0.00003489957,0.0002317654,0.003582649],"genre_scores_gemma":[0.973587,0.00004947383,0.0001609033,0.0001848978,0.00008194328,0.0001056198,0.000007386648,0.00008072404,0.0257421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02215945,"threshold_uncertainty_score":0.9998323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02733445802074041,"score_gpt":0.2524441199689575,"score_spread":0.2251096619482171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}