{"id":"W2623453429","doi":"10.1158/1557-3265.ovcasymp16-ap27","title":"Abstract AP27: FEASIBILITY OF MONITORING RESPONSE TO THE PARP INHIBITOR RUCAPARIB WITH TARGETED DEEP SEQUENCING OF CIRCULATING TUMOR DNA (CTDNA) IN WOMEN WITH HIGH GRADE OVARIAN CARCINOMA ON THE ARIEL2 TRIAL","year":2017,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; PARP inhibitor; Ovarian cancer; Internal medicine; Oncology; Cancer; Interquartile range; Cancer research; Biology; Gene; Genetics; Poly ADP ribose polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003893694,0.0004962261,0.0008652449,0.0001837278,0.0001365526,0.0009938774,0.0006470251,0.0005686379,0.003017058],"category_scores_gemma":[0.003773816,0.0001981094,0.0005474641,0.0002676349,0.0002521043,0.0006248251,0.0004374595,0.001334671,0.0005450104],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000512443,"about_ca_system_score_gemma":0.0005090745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005019378,"about_ca_topic_score_gemma":0.0007632162,"domain_scores_codex":[0.9983368,0.001101027,0.00006509,0.000246203,0.0001614097,0.00008947444],"domain_scores_gemma":[0.9980569,0.0007740167,0.0003795864,0.0001978687,0.0001727733,0.0004188537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6483629,0.002966109,0.111262,0.0006430267,0.002450683,0.0001874833,0.0001675594,0.005177734,0.0164726,0.0002372645,0.007294572,0.2047781],"study_design_scores_gemma":[0.225407,0.2424911,0.4417957,0.0002317035,0.004849948,0.0009778867,0.0003817066,0.03933292,0.02520493,0.001815519,0.01732264,0.0001889457],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910812,0.002296746,0.000725894,0.0005911728,0.00004842236,0.0002709998,0.0022576,0.0001185299,0.002609432],"genre_scores_gemma":[0.9959883,0.0002281458,0.0006987558,0.0002672501,0.00005864288,0.0002586138,0.00166091,0.00001845423,0.0008208937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003893694,"threshold_uncertainty_score":0.02059203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3201574844223511,"score_gpt":0.4925623626280325,"score_spread":0.1724048782056814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}