{"id":"W2623526312","doi":"10.1158/1557-3265.ovcasymp16-ntoc-110","title":"Abstract NTOC-110: UNEXPECTED ROLES FOR KDM4A: PROTEIN SYNTHESIS AND MTOR INHIBITOR SENSITIVITY","year":2017,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium","funders":"","keywords":"PI3K/AKT/mTOR pathway; Biology; Protein biosynthesis; Translation (biology); Translational regulation; Cancer research; Cell biology; Biochemistry; Messenger RNA; Signal transduction; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001477608,0.0002584639,0.000359665,0.0002725342,0.000319597,0.0004779755,0.0004151507,0.0003569992,0.004119209],"category_scores_gemma":[0.0002040235,0.0001564396,0.0002136568,0.0002815108,0.0003361803,0.0001727237,0.0002530389,0.0006358202,0.0008643821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006736096,"about_ca_system_score_gemma":0.000305986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001786284,"about_ca_topic_score_gemma":0.002321087,"domain_scores_codex":[0.9998274,0.00001479543,0.00001800995,0.00004576835,0.00006683725,0.00002713975],"domain_scores_gemma":[0.9998695,0.00001854896,0.00003273772,0.0000143387,0.00001992626,0.00004497117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005188804,0.00004611793,0.001251872,0.00009173806,0.00001693931,0.0002129756,0.0000136803,0.0001286281,0.9908038,0.0002588192,0.0007034485,0.005953139],"study_design_scores_gemma":[0.00006685182,0.0004311302,0.02458404,0.00001191585,0.00004100311,0.001321226,0.0000297908,0.0008782081,0.9602824,0.0002714247,0.01206859,0.00001338324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802833,0.006171311,0.002054674,0.001181652,0.0002191748,0.00005749914,0.00214072,0.0003272151,0.007564375],"genre_scores_gemma":[0.9845923,0.001653666,0.001794724,0.000254506,0.0000688474,0.00004206799,0.001989497,0.00008305278,0.009521426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004119209,"threshold_uncertainty_score":0.01378018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1248565530715546,"score_gpt":0.4652956994232142,"score_spread":0.3404391463516596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}