{"id":"W2623577366","doi":"10.1158/1557-3265.ovcasymp16-ap32","title":"Abstract AP32: THE METHYLTRANSFERASE EZH2 IS A VULNERABLE TARGET IN SMALL CELL CARCINOMA OF THE OVARY, HYPERCALCEMIC TYPE (SCCOHT)","year":2017,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Biology; SMARCA4; EZH2; Cancer research; Chromatin; Chromatin remodeling; Histone methyltransferase; Cell cycle checkpoint; Cell biology; Cell cycle; Genetics; Cell; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003038493,0.000131813,0.0002344618,0.0000267617,0.0003997172,0.00005160591,0.001239745,0.0002408847,0.0002174288],"category_scores_gemma":[0.0006928926,0.00007938528,0.0002040176,0.0001232956,0.0005959103,0.00000487131,0.0003214285,0.0009909591,0.00001244105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003844215,"about_ca_system_score_gemma":0.0007790983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005318103,"about_ca_topic_score_gemma":0.001368768,"domain_scores_codex":[0.9979885,0.0004041037,0.0004528648,0.0004419505,0.0003052202,0.0004073723],"domain_scores_gemma":[0.9979066,0.0002232125,0.0001087741,0.00138607,0.0002821153,0.00009320358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001591058,0.0005477653,0.2848141,0.0002869609,0.0001172013,0.0000144651,0.0005031837,0.000626154,0.6691844,0.00004173504,0.02287355,0.0193994],"study_design_scores_gemma":[0.002636646,0.0005244943,0.2704166,0.0001359131,0.00003323275,0.000003356191,0.0001761972,0.001174658,0.6961837,0.0007347466,0.02765292,0.0003275884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906153,0.003870051,0.00001310504,0.001918089,0.0003355543,0.0003178298,0.00004094041,0.000002945328,0.002886182],"genre_scores_gemma":[0.996116,0.001695334,0.00008319344,0.0004049716,0.0003915156,0.00004874003,0.000006019097,0.00002470434,0.001229496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02699922,"threshold_uncertainty_score":0.8039417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1792497800052143,"score_gpt":0.461124827851324,"score_spread":0.2818750478461097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}