{"id":"W2623831325","doi":"10.1021/acs.chemrev.7b00063","title":"Metal Sensing by DNA","year":2017,"lang":"en","type":"review","venue":"Chemical Reviews","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":929,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; China Scholarship Council","keywords":"Deoxyribozyme; Aptamer; DNA; Chemistry; Nanotechnology; Computational biology; Nucleobase; Combinatorial chemistry; Biosensor; Metal ions in aqueous solution; Biomolecule; Metal; Genetics; Biochemistry; Biology; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003605326,0.0009606649,0.0009325072,0.001235491,0.0003281116,0.0011029,0.0009982721,0.001442463,0.004206029],"category_scores_gemma":[0.0006537423,0.0003707675,0.0004702664,0.001293415,0.0008839252,0.001602882,0.0009339405,0.001851886,0.00660243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007975419,"about_ca_system_score_gemma":0.0006442285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006026171,"about_ca_topic_score_gemma":0.0005692342,"domain_scores_codex":[0.9995645,0.00006472675,0.00003288182,0.0001237288,0.0001744781,0.00003977744],"domain_scores_gemma":[0.9998071,0.00008105552,0.00002607918,0.00001591577,0.00005367343,0.00001623445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006013122,0.00007895247,0.000172961,0.01670438,0.00007787155,0.0003149054,0.0001961892,0.0009332498,0.1065248,0.03491768,0.03553824,0.8044806],"study_design_scores_gemma":[0.000005637404,0.00005451808,0.0001287951,0.0005968044,0.00001789212,0.0005502257,0.00003485359,0.0001455473,0.02701648,0.002454704,0.968973,0.00002143159],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001212615,0.9765399,0.006252077,0.0008187632,0.001349179,0.00003705915,0.0001535505,0.0001461849,0.0134908],"genre_scores_gemma":[0.0117242,0.9694151,0.004577644,0.0008906398,0.0005355224,0.0000902089,0.0002786926,0.00002668463,0.01246119],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004206029,"threshold_uncertainty_score":0.01407057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0817482560434721,"score_gpt":0.404721555813443,"score_spread":0.3229732997699709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}