{"id":"W2623838690","doi":"10.1074/jbc.m117.793877","title":"Conformational biosensors reveal allosteric interactions between heterodimeric AT1 angiotensin and prostaglandin F2α receptors","year":2017,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Allosteric regulation; G protein-coupled receptor; Chemistry; Receptor; Biophysics; Förster resonance energy transfer; Signal transduction; Angiotensin II; Intracellular; Cell biology; Biochemistry; Biology; Fluorescence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005562641,0.0002845963,0.0003370977,0.0001682117,0.0001645715,0.000492506,0.0005061409,0.0005860712,0.001423394],"category_scores_gemma":[0.0007647098,0.000215785,0.0002004201,0.0001919345,0.0004440774,0.0005057233,0.0002642711,0.001091827,0.0003781969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004106688,"about_ca_system_score_gemma":0.0001319163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002713514,"about_ca_topic_score_gemma":0.0004450421,"domain_scores_codex":[0.9996157,0.0000858489,0.00002555032,0.00008642275,0.0001128043,0.00007370758],"domain_scores_gemma":[0.9996876,0.0001522586,0.00004293955,0.00005753426,0.00002538549,0.00003433877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008377361,0.00003252916,0.0001285955,0.00001938227,0.000004583684,0.00002332022,0.00002307679,0.0001284561,0.9973034,0.0005252875,0.00007067974,0.001656832],"study_design_scores_gemma":[0.00002554739,0.0001394721,0.001955297,0.000004604421,0.00001228416,0.0001495768,0.00005350391,0.006578063,0.9896801,0.0003986039,0.0009906109,0.00001234076],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825031,0.0003804741,0.01500862,0.0002622113,0.00008636984,0.00002000886,0.0001502003,0.0001277893,0.001461396],"genre_scores_gemma":[0.9935458,0.0002339117,0.004585555,0.0001285006,0.00001415943,0.00003042443,0.0001364491,0.00002195867,0.001303211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001423394,"threshold_uncertainty_score":0.004761696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03224552454196462,"score_gpt":0.2810287025948252,"score_spread":0.2487831780528605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}