{"id":"W2623838690","doi":"10.1074/jbc.m117.793877","title":"Conformational biosensors reveal allosteric interactions between heterodimeric AT1 angiotensin and prostaglandin F2α receptors","year":2017,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Allosteric regulation; G protein-coupled receptor; Chemistry; Receptor; Biophysics; Förster resonance energy transfer; Signal transduction; Angiotensin II; Intracellular; Cell biology; Biochemistry; Biology; Fluorescence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002768063,0.0001518952,0.0002494318,0.00002140784,0.0002418753,0.00009121969,0.0002318659,0.0001979832,0.0001065375],"category_scores_gemma":[0.0002659007,0.0001088519,0.0001461491,0.0000222311,0.0001566656,0.000017898,0.0001302887,0.0002229155,0.000002910002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001640004,"about_ca_system_score_gemma":0.00002604533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002052307,"about_ca_topic_score_gemma":2.43733e-7,"domain_scores_codex":[0.9990991,0.00003510635,0.000393828,0.0001749409,0.0001195661,0.000177396],"domain_scores_gemma":[0.9989175,0.00002395476,0.0005833589,0.0001876049,0.0001431193,0.0001444976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001051921,0.00002243235,0.0114773,0.00001252067,0.00007502212,0.000006334297,0.00001846944,0.00000248813,0.9849635,0.00000197738,0.001126824,0.002187875],"study_design_scores_gemma":[0.0005955389,0.0003741955,0.01515976,0.00006469605,0.00002707857,0.0003966085,0.00009486894,0.000009472019,0.9525559,0.00006738648,0.03043737,0.0002171568],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983559,0.000277293,0.0002388745,0.000430051,0.0002117729,0.00005571937,0.00002286817,0.000004453425,0.0004030146],"genre_scores_gemma":[0.9973322,0.000239929,0.001258856,0.0000799751,0.0007654607,0.000001513337,0.00006389397,0.000008449654,0.0002497346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03240769,"threshold_uncertainty_score":0.4438851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03224552454196462,"score_gpt":0.2810287025948252,"score_spread":0.2487831780528605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}