{"id":"W2624062961","doi":"10.1002/dvdy.24532","title":"Xenopus pitx3 target genes lhx1 and xnr5 are identified using a novel three‐fluor flow cytometry–based analysis of promoter activation and repression","year":2017,"lang":"en","type":"article","venue":"Developmental Dynamics","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Flow cytometry; Transcription factor; Somitogenesis; Promoter; Xenopus; Cell biology; Gene; Molecular biology; Genetics; Embryonic stem cell; Gene expression; Somite","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000191584,0.0001751923,0.000239228,0.0001793944,0.0003269289,0.0000525234,0.0001298171,0.0002052976,0.00000851758],"category_scores_gemma":[0.00006070905,0.0001664955,0.00005338487,0.0001352477,0.0001590298,0.00002380613,0.0002333638,0.0000516396,3.702573e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004959475,"about_ca_system_score_gemma":0.00006157508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003889814,"about_ca_topic_score_gemma":0.0002269555,"domain_scores_codex":[0.9990155,0.00002176134,0.0002609182,0.0004201095,0.0001216152,0.0001601448],"domain_scores_gemma":[0.9992879,0.000009261577,0.0003254641,0.0002444969,0.000077073,0.00005581404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00007337494,0.00003761801,0.4353627,0.00002561585,0.0002702757,7.144603e-7,0.00003071339,0.000214178,0.5597317,0.000006478782,0.000002210419,0.004244449],"study_design_scores_gemma":[0.0004331593,0.00002486979,0.6809034,0.00003289479,0.0000850556,0.000006652579,0.00004612011,0.05647114,0.2617589,0.00002684978,0.00003220365,0.0001787952],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9549753,0.00009286117,0.04449843,0.00004752377,0.00008116614,0.000182728,0.00007677789,0.000007017903,0.00003819049],"genre_scores_gemma":[0.9492363,0.00002611559,0.04968585,0.00003667552,0.00001731014,0.000008415205,0.0009042146,0.00001326644,0.00007187549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2979727,"threshold_uncertainty_score":0.678949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01737859791796643,"score_gpt":0.2663952856117062,"score_spread":0.2490166876937398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}