{"id":"W2624275086","doi":"10.1038/ncomms15618","title":"DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":1726,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Center for Research Resources; National Cancer Institute; National Institutes of Health; York University; Chemotherapy Foundation; Breast Cancer Research Foundation; Weill Cornell Medical College; U.S. Department of Defense","keywords":"Abscopal effect; Context (archaeology); Immunogenicity; Cancer research; CD8; Effector; DNA damage; Immunotherapy; Cancer immunotherapy; Immune system; Biology; Cell biology; DNA; Immunology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001308816,0.0001674348,0.0001992992,0.0001074065,0.0001221356,0.0003072098,0.00009323879,0.0002068068,0.001971319],"category_scores_gemma":[0.0001349641,0.00009048793,0.0001637522,0.00006516847,0.0001418259,0.0001512218,0.0001444366,0.000433739,0.0004742613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002435236,"about_ca_system_score_gemma":0.0001082351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001753034,"about_ca_topic_score_gemma":0.0002098641,"domain_scores_codex":[0.9999104,0.00001676352,0.000005654637,0.00002304995,0.00001706581,0.00002716318],"domain_scores_gemma":[0.9998637,0.0000247221,0.00005894983,0.000009095369,0.00001897647,0.00002448953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000161012,0.00001418557,0.0007182299,0.00001997046,0.000002357743,0.00003518353,0.0000113385,0.00006027451,0.9979861,0.00004099212,0.00003191632,0.0009183856],"study_design_scores_gemma":[0.00001443159,0.0003297551,0.02893676,0.00001035396,0.00001004217,0.0003352631,0.00003979044,0.0008497935,0.9678338,0.00007224639,0.001563072,0.000004751851],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947097,0.002558567,0.001361671,0.00008560265,0.00001603355,0.0000149606,0.0001972662,0.00004658292,0.001009522],"genre_scores_gemma":[0.9977202,0.0004379134,0.0003956003,0.00002361749,0.000004845397,0.000007517949,0.0001652396,0.000009250579,0.001235895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001971319,"threshold_uncertainty_score":0.006594658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02633925884840929,"score_gpt":0.3114498854488363,"score_spread":0.285110626600427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}