{"id":"W2624331100","doi":"10.1002/jlcr.3528","title":"“In‐loop” [<sup>11</sup>C]CO<sub>2</sub> fixation: Prototype and proof of concept","year":2017,"lang":"en","type":"article","venue":"Journal of Labelled Compounds and Radiopharmaceuticals","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health","funders":"National Institute on Drug Abuse; National Institute on Aging; National Institutes of Health; China Scholarship Council","keywords":"Chemistry; Carbon fixation; Amide; Carbonylation; Radiochemistry; Specific activity; Carbon dioxide; Combinatorial chemistry; Organic chemistry; Enzyme; Catalysis; Carbon monoxide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004057501,0.0005123758,0.0002155228,0.0001485221,0.0001548639,0.0002930483,0.0008847623,0.0008026417,0.001617474],"category_scores_gemma":[0.0002174343,0.0002570187,0.0001871755,0.0001106937,0.0003679437,0.0005630487,0.0002351405,0.0005603047,0.0006912622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003532491,"about_ca_system_score_gemma":0.0004260198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006885277,"about_ca_topic_score_gemma":0.000755008,"domain_scores_codex":[0.9998646,0.00001755147,0.000006292581,0.00002975163,0.00005726071,0.00002451643],"domain_scores_gemma":[0.9998769,0.000015279,0.00004455986,0.00001353365,0.00002632766,0.00002334206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008695615,0.00004150968,0.00005205835,0.0001129787,0.00000771372,0.000115629,0.00002484398,0.0001899862,0.9943613,0.0004386641,0.0004827733,0.004085425],"study_design_scores_gemma":[0.00002611706,0.0005169262,0.0003115961,0.000005810649,0.00001328215,0.0002826262,0.00001481969,0.001082549,0.9884782,0.00004949935,0.009204732,0.00001369711],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.704111,0.003384543,0.2764797,0.0008456243,0.000499724,0.001183107,0.001116362,0.002248297,0.01013167],"genre_scores_gemma":[0.8195097,0.001992422,0.1675035,0.0002978259,0.00008206592,0.0005642953,0.0007472975,0.0002093577,0.009093526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001617474,"threshold_uncertainty_score":0.005410969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02414888250972251,"score_gpt":0.3276206352472674,"score_spread":0.3034717527375449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}