{"id":"W2624341173","doi":"10.1200/jco.2017.35.15_suppl.104","title":"Preliminary results of a phase I/IIa study of BMS-986156 (glucocorticoid-induced tumor necrosis factor receptor–related gene [GITR] agonist), alone and in combination with nivolumab in pts with advanced solid tumors.","year":2017,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Nivolumab; Pharmacology; Pharmacodynamics; Immunogenicity; Adverse effect; Internal medicine; Pharmacokinetics; Cancer; Immunotherapy; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002120484,0.001843726,0.001526094,0.0003952343,0.0005138487,0.0009004393,0.0008097343,0.001271612,0.002786765],"category_scores_gemma":[0.001152776,0.0006025267,0.001411558,0.000387216,0.0008695791,0.0008333907,0.0002794205,0.002810271,0.0009951058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009032282,"about_ca_system_score_gemma":0.001390505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001074342,"about_ca_topic_score_gemma":0.002565932,"domain_scores_codex":[0.9994156,0.0002985491,0.00004560053,0.00008032106,0.00005822454,0.0001016539],"domain_scores_gemma":[0.9990778,0.0001893834,0.0001309807,0.00009276174,0.00007367734,0.0004352549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4470819,0.1496668,0.01527647,0.001096782,0.002347118,0.00131455,0.0008096296,0.006161426,0.2550282,0.0002899363,0.00697302,0.1139542],"study_design_scores_gemma":[0.195608,0.7515228,0.02473763,0.00004589657,0.0009516745,0.00102894,0.0001075585,0.001635656,0.01949524,0.0002346942,0.004592443,0.00003940738],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893662,0.001332287,0.001336987,0.0005908358,0.00009585881,0.003188642,0.001489084,0.0001075886,0.002492299],"genre_scores_gemma":[0.9840629,0.00156238,0.003834962,0.0009152568,0.0001529621,0.002138954,0.004588367,0.00005544244,0.002688754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002786765,"threshold_uncertainty_score":0.01121432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06905777210190539,"score_gpt":0.4292556546783504,"score_spread":0.360197882576445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}