{"id":"W2624484247","doi":"10.1007/s12079-017-0398-2","title":"Matricellular proteins in cancer: a focus on secreted Frizzled-related proteins","year":2017,"lang":"en","type":"article","venue":"Journal of Cell Communication and Signaling","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Western University","funders":"Canadian Institutes of Health Research; Alberta Innovates","keywords":"Matricellular protein; Biology; Cell biology; Cancer cell; Frizzled; Wnt signaling pathway; Extracellular matrix; Cancer; Tumor microenvironment; Stromal cell; Tumor progression; Metastasis; Cancer research; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006878331,0.0001294507,0.0001954049,0.0001003339,0.0002700821,0.00009517113,0.0005289695,0.0001390385,0.00004512597],"category_scores_gemma":[0.00006863166,0.0001145969,0.00007263777,0.00005843586,0.00007259381,0.00001697359,0.0001187728,0.0003018646,0.000001885548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003383999,"about_ca_system_score_gemma":0.0001356942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006459333,"about_ca_topic_score_gemma":0.00002953127,"domain_scores_codex":[0.9989727,0.0001279604,0.0004391886,0.0001362929,0.0001757448,0.0001480938],"domain_scores_gemma":[0.9986303,0.00002094448,0.0006925321,0.0004278726,0.0001591535,0.00006915742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000223036,0.00008839325,0.003767982,0.00002858061,0.00005186818,0.000007357544,0.0003653446,0.0002916083,0.9924837,0.00007931897,0.000124939,0.002487856],"study_design_scores_gemma":[0.002192669,0.0003237614,0.002675854,0.0003855583,0.00003191536,0.00001336039,0.0001551987,0.0002834286,0.9889773,0.0009071024,0.003810129,0.0002437894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907622,0.006001467,0.0003531809,0.0006738986,0.00006573866,0.0002355516,0.000001952156,0.000004229241,0.001901775],"genre_scores_gemma":[0.9950399,0.002429572,0.001903564,0.00006077101,0.00006700084,0.00002094878,0.000007192056,0.00001739954,0.0004536763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004277669,"threshold_uncertainty_score":0.4673127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01658273437173019,"score_gpt":0.267835923204459,"score_spread":0.2512531888327288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}