{"id":"W2624697958","doi":"10.1039/c7nr01582h","title":"Diruthenium(<scp>ii</scp>,<scp>iii</scp>) metallodrugs of ibuprofen and naproxen encapsulated in intravenously injectable polymer–lipid nanoparticles exhibit enhanced activity against breast and prostate cancer cells","year":2017,"lang":"en","type":"article","venue":"Nanoscale","topic":"Ferrocene Chemistry and Applications","field":"Chemistry","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Public Health; University of Toronto","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Natural Sciences and Engineering Research Council of Canada; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Naproxen; Ibuprofen; Chemistry; Nanoparticle; Polymer; Prostate cancer; Cancer; Combinatorial chemistry; Pharmacology; Nanotechnology; Materials science; Medicine; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002109529,0.0004173482,0.0006064177,0.00005957637,0.0005691808,0.0001284086,0.0004635989,0.000325468,0.00001626813],"category_scores_gemma":[0.0001772365,0.000415066,0.0000817641,0.0001862859,0.000494392,0.0004044581,0.0004217545,0.0003963837,0.000004506419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007568407,"about_ca_system_score_gemma":0.0001607191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008660705,"about_ca_topic_score_gemma":0.0001987998,"domain_scores_codex":[0.9977407,0.00003379601,0.0004904029,0.0007706282,0.0002865256,0.0006779875],"domain_scores_gemma":[0.9980401,0.0002521929,0.0005255822,0.0007987536,0.0001233615,0.0002599949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003682767,0.0003850349,0.002550761,0.0003709483,0.00007103621,0.000004183028,0.003170597,0.00001141503,0.9890007,0.00001519616,0.0001483738,0.004234869],"study_design_scores_gemma":[0.001544729,0.00003346498,0.003037138,0.0002379806,0.00007071509,0.00001106133,0.0009526744,0.0002009037,0.9932105,0.00008841946,0.0004682763,0.0001441398],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933375,0.000935622,0.000003901885,0.0001317318,0.00005681847,0.0003321665,0.0003954283,0.00007896005,0.004727847],"genre_scores_gemma":[0.9922872,0.0005945482,0.00006083021,0.00003043629,0.00009792225,0.000220899,0.00003396261,0.00005344574,0.00662079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00420974,"threshold_uncertainty_score":0.9998301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007921952384300327,"score_gpt":0.2318866182497006,"score_spread":0.2239646658654003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}