{"id":"W2624697958","doi":"10.1039/c7nr01582h","title":"Diruthenium(<scp>ii</scp>,<scp>iii</scp>) metallodrugs of ibuprofen and naproxen encapsulated in intravenously injectable polymer–lipid nanoparticles exhibit enhanced activity against breast and prostate cancer cells","year":2017,"lang":"en","type":"article","venue":"Nanoscale","topic":"Ferrocene Chemistry and Applications","field":"Chemistry","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Public Health; University of Toronto","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Natural Sciences and Engineering Research Council of Canada; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Naproxen; Ibuprofen; Chemistry; Nanoparticle; Polymer; Prostate cancer; Cancer; Combinatorial chemistry; Pharmacology; Nanotechnology; Materials science; Medicine; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001072427,0.0002979542,0.0001987568,0.0001035713,0.00007233548,0.0001575677,0.0001049738,0.0002395717,0.0006065842],"category_scores_gemma":[0.00008797286,0.0001002699,0.0001288855,0.00006007371,0.0001719369,0.0001447499,0.00009066647,0.0002213794,0.0001326859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002549716,"about_ca_system_score_gemma":0.0001373701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009240822,"about_ca_topic_score_gemma":0.001411109,"domain_scores_codex":[0.9999379,0.000007508764,0.000004106741,0.00001470899,0.00001740495,0.00001845305],"domain_scores_gemma":[0.9999502,0.00000916117,0.00001952194,0.000003630249,0.000006260813,0.00001117972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003218422,0.000004460278,0.00002701085,0.00001202476,0.000001536309,0.00001137817,0.000006337086,0.00002956783,0.9993574,0.0000234367,0.00001081897,0.0004838525],"study_design_scores_gemma":[0.00000473104,0.0001427745,0.0003131733,0.000001078281,0.000004431666,0.00003053055,0.000003613644,0.0001294919,0.9990168,0.000003300084,0.0003489099,0.00000109829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951993,0.0009343072,0.001918819,0.00004428188,0.0000114206,0.00002924778,0.00008257905,0.00006327487,0.001716971],"genre_scores_gemma":[0.9953817,0.0004229244,0.002047075,0.00002221933,0.000004195063,0.00001766098,0.00009099078,0.00001471586,0.001998539],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009240822,"threshold_uncertainty_score":0.00202924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007921952384300327,"score_gpt":0.2318866182497006,"score_spread":0.2239646658654003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}