{"id":"W2624741517","doi":"10.3390/ijms18061254","title":"Experimental Autoimmune Encephalomyelitis (EAE)-Induced Elevated Expression of the E1 Isoform of Methyl CpG Binding Protein 2 (MeCP2E1): Implications in Multiple Sclerosis (MS)-Induced Neurological Disability and Associated Myelin Damage","year":2017,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"University of Manitoba; Manitoba Medical Service Foundation","keywords":"Experimental autoimmune encephalomyelitis; Multiple sclerosis; Myelin; Myelin basic protein; Immunology; Encephalomyelitis; Brain-derived neurotrophic factor; Central nervous system; Neurotrophic factors; Proteolipid protein 1; Biology; Gene isoform; Medicine; Neuroscience; Internal medicine; Receptor; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009161999,0.000312595,0.0002209421,0.0003406784,0.0001333265,0.0001911183,0.0001053792,0.0003374447,0.0006532419],"category_scores_gemma":[0.00007431737,0.0000907669,0.0001880571,0.0002162754,0.0002385751,0.0001580771,0.0001563369,0.000555602,0.000164969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002228443,"about_ca_system_score_gemma":0.0001559428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005651496,"about_ca_topic_score_gemma":0.0009359519,"domain_scores_codex":[0.9998984,0.000009045358,0.00001047162,0.00002900989,0.00002268228,0.00003034655],"domain_scores_gemma":[0.9998944,0.00001271138,0.00004191294,0.000005637446,0.00001185155,0.00003344327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001917417,0.00004278527,0.0005580459,0.00003385016,0.0000033075,0.00005228087,0.000009832937,0.0000127866,0.9983706,0.00001299078,0.0000106739,0.0007010944],"study_design_scores_gemma":[0.00002415635,0.00147693,0.06240786,0.00001544684,0.00003644555,0.0007788697,0.00006831644,0.0003736561,0.9334868,0.00005928884,0.001263948,0.000008286524],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951071,0.002538424,0.001220944,0.00006267017,0.0000233816,0.00003396534,0.0003900114,0.00003885598,0.0005847556],"genre_scores_gemma":[0.9922584,0.002373393,0.002120018,0.00008298712,0.00001759808,0.00006639457,0.0006338916,0.000009143791,0.002438169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006532419,"threshold_uncertainty_score":0.002185285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04220942599680456,"score_gpt":0.2963148351391327,"score_spread":0.2541054091423282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}