{"id":"W2624741517","doi":"10.3390/ijms18061254","title":"Experimental Autoimmune Encephalomyelitis (EAE)-Induced Elevated Expression of the E1 Isoform of Methyl CpG Binding Protein 2 (MeCP2E1): Implications in Multiple Sclerosis (MS)-Induced Neurological Disability and Associated Myelin Damage","year":2017,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"University of Manitoba; Manitoba Medical Service Foundation","keywords":"Experimental autoimmune encephalomyelitis; Multiple sclerosis; Myelin; Myelin basic protein; Immunology; Encephalomyelitis; Brain-derived neurotrophic factor; Central nervous system; Neurotrophic factors; Proteolipid protein 1; Biology; Gene isoform; Medicine; Neuroscience; Internal medicine; Receptor; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005054979,0.0001117159,0.0001627724,0.00006504436,0.0001649873,0.0000544062,0.0009443936,0.00008181872,0.000007364318],"category_scores_gemma":[0.0006400598,0.00008271907,0.0001047258,0.00009524377,0.0004267183,0.00002775597,0.0004160485,0.0001194517,1.063548e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002155585,"about_ca_system_score_gemma":0.00009517947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000712302,"about_ca_topic_score_gemma":0.00002289883,"domain_scores_codex":[0.9986489,0.0001248651,0.0004593969,0.0002291199,0.0003948471,0.0001428997],"domain_scores_gemma":[0.99888,0.00002444298,0.0006677865,0.0002124213,0.0001731325,0.00004225543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004512356,0.0001565157,0.04209578,0.000002230133,0.0000188245,0.000001669695,0.00006350131,0.00003322449,0.9564939,0.00003758596,0.000001204992,0.001050446],"study_design_scores_gemma":[0.0003908644,0.000176394,0.4605071,0.0000400959,0.000002764795,0.000003674606,0.00005571374,0.00006557669,0.5386402,0.00006966557,0.000002772398,0.00004519282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989437,0.00007152966,0.00005151483,0.0005482694,0.0001491983,0.0001775431,0.00001772336,0.000001521366,0.00003895159],"genre_scores_gemma":[0.9993045,0.0000249286,0.0006066579,0.00003141373,0.000007837953,0.00001140755,0.000003427441,0.000005850753,0.000003955891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4184113,"threshold_uncertainty_score":0.3373186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04220942599680456,"score_gpt":0.2963148351391327,"score_spread":0.2541054091423282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}