{"id":"W2624994883","doi":"10.1182/blood.v128.22.87.87","title":"Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of a Single-Dose Oral Solution of Dabigatran Given after Standard Anticoagulant Therapy in Children (Two Age Groups: 1-<2 and 2-<12 Years Old), with Venous Thromboembolism","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Children's Hospital of Eastern Ontario; University of Ottawa","funders":"","keywords":"Medicine; Dabigatran; Tolerability; Dosing; Pharmacodynamics; Pharmacokinetics; Heparin; Anesthesia; Warfarin; Adverse effect; Internal medicine; Pharmacology; Atrial fibrillation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006492872,0.0005009899,0.00111986,0.000252599,0.0002392663,0.0005522678,0.0003039099,0.0005079977,0.001246409],"category_scores_gemma":[0.001686048,0.0003376611,0.0006801345,0.0002823435,0.0006876103,0.0006075436,0.0001838137,0.001152579,0.0002648025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005292009,"about_ca_system_score_gemma":0.0005877566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008926484,"about_ca_topic_score_gemma":0.0007503426,"domain_scores_codex":[0.9996056,0.0001597513,0.00003311586,0.00006900221,0.00005936422,0.00007325736],"domain_scores_gemma":[0.999057,0.000263844,0.0003023449,0.00005892788,0.00004676215,0.0002710171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6381554,0.04547433,0.1101978,0.0005704966,0.001090407,0.0008899341,0.0008195189,0.003142247,0.1188858,0.0002669252,0.001174762,0.07933236],"study_design_scores_gemma":[0.05557998,0.7823321,0.1351931,0.00003096531,0.0005314168,0.001210278,0.0002673536,0.002963098,0.01987065,0.00007357646,0.001885301,0.00006206783],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99933,0.000275241,0.0001092196,0.00001809655,0.000008330159,0.00007480624,0.00006470767,0.000005947809,0.0001135949],"genre_scores_gemma":[0.9988625,0.0001981364,0.0003646766,0.00005867704,0.00003155521,0.0001111241,0.000203597,0.000003211554,0.0001665972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001246409,"threshold_uncertainty_score":0.004169703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02235467389735531,"score_gpt":0.2975474512377221,"score_spread":0.2751927773403668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}