{"id":"W2624994883","doi":"10.1182/blood.v128.22.87.87","title":"Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of a Single-Dose Oral Solution of Dabigatran Given after Standard Anticoagulant Therapy in Children (Two Age Groups: 1-<2 and 2-<12 Years Old), with Venous Thromboembolism","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Children's Hospital of Eastern Ontario; University of Ottawa","funders":"","keywords":"Medicine; Dabigatran; Tolerability; Dosing; Pharmacodynamics; Pharmacokinetics; Heparin; Anesthesia; Warfarin; Adverse effect; Internal medicine; Pharmacology; Atrial fibrillation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003960783,0.000198757,0.0006809864,0.00006468065,0.00003734098,0.00001057935,0.00006839151,0.00005761877,0.00004561682],"category_scores_gemma":[0.00004011813,0.0001313423,0.00005035535,0.0001078111,0.0004809713,0.0001379114,0.00007170673,0.0001531405,3.776594e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000319626,"about_ca_system_score_gemma":0.00003300512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001868836,"about_ca_topic_score_gemma":0.0001077899,"domain_scores_codex":[0.9985868,0.0001282668,0.0003986089,0.000322793,0.000273037,0.0002905282],"domain_scores_gemma":[0.9993162,0.0001435186,0.0001638398,0.0001723769,0.00006884374,0.0001351848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00864994,0.002862895,0.5348812,0.0002038631,0.0008828275,0.000103718,0.001386054,0.000002238626,0.3829426,0.00003277603,0.000009204471,0.06804272],"study_design_scores_gemma":[0.02498003,0.001980965,0.9511302,0.0002671677,0.0006449182,0.0001040634,0.00003448034,0.00005977495,0.01996692,0.000097272,0.0005247249,0.0002095206],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952508,0.003087322,0.00006330548,0.0005882631,0.00004375847,0.0006585399,0.0001930319,0.00001935717,0.0000956849],"genre_scores_gemma":[0.9926043,0.006742876,0.0004224767,0.0001187634,0.00006631116,0.000008860954,0.00000825438,0.00002252583,0.000005681749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.416249,"threshold_uncertainty_score":0.5355986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02235467389735531,"score_gpt":0.2975474512377221,"score_spread":0.2751927773403668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}