{"id":"W2625253716","doi":"10.1038/leu.2017.138","title":"Natural history of relapsed myeloma, refractory to immunomodulatory drugs and proteasome inhibitors: a multicenter IMWG study","year":2017,"lang":"en","type":"article","venue":"Leukemia","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":354,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Janssen Pharmaceuticals","keywords":"Multiple myeloma; Medicine; Internal medicine; Carfilzomib; Oncology; Proteasome inhibitor; Lenalidomide; Refractory (planetary science); Hematology; Natural history; Pomalidomide; Bortezomib; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001338981,0.0007200821,0.0009934983,0.0006274896,0.0006989065,0.0009156317,0.0007687939,0.0008660401,0.0009877976],"category_scores_gemma":[0.001334651,0.0004069034,0.0007283863,0.001123616,0.0005417214,0.001151563,0.000696369,0.0008122142,0.0003292864],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007755916,"about_ca_system_score_gemma":0.0005236489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001512976,"about_ca_topic_score_gemma":0.001310011,"domain_scores_codex":[0.9992996,0.0002334304,0.00004794225,0.0002209023,0.00006028711,0.0001378347],"domain_scores_gemma":[0.9989078,0.0001076282,0.0003881646,0.000147107,0.00007619731,0.0003730647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01123436,0.0007987191,0.9797561,0.00003345764,0.0003629967,0.0003641598,0.0002739149,0.0001429663,0.001546997,0.00005108044,0.000394479,0.005040757],"study_design_scores_gemma":[0.0008429508,0.003148291,0.9934209,0.00001295307,0.0003173709,0.0007657622,0.0002842448,0.0002880183,0.0002133181,0.00006865545,0.000621161,0.00001649425],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991791,0.000274712,0.00003468397,0.00003072718,0.000002883045,0.00002398512,0.0002689252,0.000003502987,0.0001815124],"genre_scores_gemma":[0.9986884,0.0001056892,0.00006476364,0.00006676131,0.00002451637,0.00003367236,0.0008357497,0.000004509851,0.0001759092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001512976,"threshold_uncertainty_score":0.00708133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01825545139266853,"score_gpt":0.293698689027516,"score_spread":0.2754432376348475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}