{"id":"W2625253716","doi":"10.1038/leu.2017.138","title":"Natural history of relapsed myeloma, refractory to immunomodulatory drugs and proteasome inhibitors: a multicenter IMWG study","year":2017,"lang":"en","type":"article","venue":"Leukemia","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":354,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Janssen Pharmaceuticals","keywords":"Multiple myeloma; Medicine; Internal medicine; Carfilzomib; Oncology; Proteasome inhibitor; Lenalidomide; Refractory (planetary science); Hematology; Natural history; Pomalidomide; Bortezomib; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002864379,0.0002380055,0.0004473811,0.0001868475,0.0001567614,0.00003032895,0.0002302972,0.00009816822,0.00004975686],"category_scores_gemma":[0.0004769954,0.0001924958,0.0001005858,0.00004015762,0.0002089762,0.0002440816,0.0002622742,0.0003546265,0.00005163478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002151622,"about_ca_system_score_gemma":0.0005314268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001349471,"about_ca_topic_score_gemma":0.00007141929,"domain_scores_codex":[0.9982309,0.00008422496,0.0003477901,0.0004439914,0.0005202277,0.0003728945],"domain_scores_gemma":[0.9981385,0.00005869199,0.0002100171,0.001097922,0.000162458,0.0003323347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008658757,0.00238093,0.6440898,0.0005987409,0.001182372,0.0009841169,0.01888959,0.000001090175,0.2050663,0.00001756633,0.009565456,0.1085653],"study_design_scores_gemma":[0.01158385,0.001251831,0.9746183,0.0002790659,0.00008262097,0.000012721,0.000548155,0.000150109,0.003036104,0.000004803076,0.008232309,0.000200177],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942818,0.001264949,0.0000010452,0.0001484605,0.0004378142,0.002065084,0.000007706612,0.00004338324,0.001749818],"genre_scores_gemma":[0.9901871,0.00001654073,0.0004038933,0.00009736788,0.0001558572,0.0001468968,0.00001015976,0.00003858518,0.008943603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3305285,"threshold_uncertainty_score":0.7849751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01825545139266853,"score_gpt":0.293698689027516,"score_spread":0.2754432376348475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}