{"id":"W2625315254","doi":"10.1161/hyp.64.suppl_1.530","title":"Abstract 530: Enhanced Expression Of Epithelial Sodium Channels (ENaC) Causes Salt-induced Hypertension In Mice Through Inhibition Of The α 2 -isoform Of Na + , K + -atpase","year":2014,"lang":"en","type":"article","venue":"Hypertension","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Heart Institute","funders":"","keywords":"Epithelial sodium channel; Endocrinology; Internal medicine; Gene isoform; Chemistry; Ouabain; Knockout mouse; Sodium; Homeostasis; Molecular biology; Receptor; Biology; Medicine; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000174792,0.0008902959,0.0004999142,0.0004699895,0.0002851474,0.0004300447,0.0004331841,0.0006151168,0.006892333],"category_scores_gemma":[0.00009842961,0.0003645308,0.000584493,0.000202595,0.0006401309,0.0004015545,0.0003292494,0.00189042,0.001396761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005958862,"about_ca_system_score_gemma":0.0002811395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00120083,"about_ca_topic_score_gemma":0.001640811,"domain_scores_codex":[0.9997013,0.00002693833,0.00004572524,0.00008775742,0.00008126559,0.00005696495],"domain_scores_gemma":[0.9997848,0.00001503405,0.000073841,0.0000164774,0.00001853655,0.00009126691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000212629,0.00004588165,0.0001160508,0.00003912052,0.000006805743,0.00007946358,0.00001291465,0.00002592499,0.9988577,0.0001242406,0.0001062965,0.0003728463],"study_design_scores_gemma":[0.0000911443,0.0004072028,0.004119931,0.00001616289,0.0000400342,0.0004773157,0.00004600303,0.0005446626,0.990106,0.00006938934,0.004073428,0.000008825702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9767165,0.001171347,0.008066915,0.0007650803,0.0003286182,0.0001206944,0.007073876,0.0006844255,0.005072534],"genre_scores_gemma":[0.9456383,0.001934482,0.01145367,0.0005888438,0.00007431053,0.0003270004,0.005896172,0.0003997317,0.03368744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006892333,"threshold_uncertainty_score":0.0230571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0150417464721729,"score_gpt":0.2144888435895176,"score_spread":0.1994470971173447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}