{"id":"W2625315254","doi":"10.1161/hyp.64.suppl_1.530","title":"Abstract 530: Enhanced Expression Of Epithelial Sodium Channels (ENaC) Causes Salt-induced Hypertension In Mice Through Inhibition Of The α <sub>2</sub> -isoform Of Na <sup>+</sup> , K <sup>+</sup> -atpase","year":2014,"lang":"en","type":"article","venue":"Hypertension","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Heart Institute","funders":"","keywords":"Epithelial sodium channel; Endocrinology; Internal medicine; Gene isoform; Chemistry; Ouabain; Knockout mouse; Sodium; Homeostasis; Molecular biology; Receptor; Biology; Medicine; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004009614,0.0003970978,0.000636883,0.0001510561,0.00013189,0.000009817743,0.0002392786,0.0005585373,0.00001039734],"category_scores_gemma":[0.000174882,0.000301095,0.0003151976,0.0003147941,0.0001824481,0.00005099813,0.0001225448,0.0002313513,0.000005554971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003012543,"about_ca_system_score_gemma":0.0001021636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001845526,"about_ca_topic_score_gemma":0.00002879966,"domain_scores_codex":[0.997346,0.0001444604,0.0009571168,0.0006003677,0.0005254666,0.0004265915],"domain_scores_gemma":[0.9981337,0.00006746296,0.0005529818,0.0006396922,0.0005191542,0.00008707577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006225446,0.0003291355,0.0001301882,0.0002210836,0.00002246564,0.000003692832,0.0006128973,0.007067396,0.9891647,0.00001401598,0.0001616455,0.001650306],"study_design_scores_gemma":[0.002142168,0.0004015541,0.003996359,0.0007502717,0.00006450843,0.00001803276,0.000448441,0.003837042,0.9877804,0.0001446068,0.0001001841,0.0003164163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997982,0.0001961775,0.0007727066,0.0001231429,0.0002463661,0.0005327813,0.00004637049,0.00002198756,0.00007851389],"genre_scores_gemma":[0.9986621,0.0002957051,0.0001561324,0.0002078121,0.0002694165,0.00002414965,0.0003068681,0.0000609545,0.00001682784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003866171,"threshold_uncertainty_score":0.9999441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0150417464721729,"score_gpt":0.2144888435895176,"score_spread":0.1994470971173447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}