{"id":"W2625374800","doi":"10.1161/res.117.suppl_1.129","title":"Abstract 129: Inhibition of MEF2 By Atenolol Modifies the Transcriptome During Cardiac Hypertrophy to Improve Heart Function","year":2015,"lang":"en","type":"article","venue":"Circulation Research","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"","keywords":"Atenolol; Muscle hypertrophy; Cardiac function curve; Internal medicine; Mef2; Fibrosis; Endocrinology; Cardiac fibrosis; Medicine; Pressure overload; Heart failure; Cardiology; Biology; Gene expression; Enhancer; Blood pressure; Cardiac hypertrophy; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001112361,0.0001006188,0.0002520967,0.0002161924,0.0001645381,0.00004304232,0.00004599678,0.0001124579,0.00002161793],"category_scores_gemma":[0.000132337,0.00007334301,0.0001765496,0.0004191204,0.0001080647,0.0001376232,0.00003011475,0.0003089868,0.00006037882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001621677,"about_ca_system_score_gemma":0.0001025963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004657817,"about_ca_topic_score_gemma":0.00000161763,"domain_scores_codex":[0.9981126,0.0001029025,0.0002946891,0.0002667608,0.0009370287,0.0002859997],"domain_scores_gemma":[0.9986886,0.00005406694,0.00003703522,0.0003269451,0.0007130151,0.0001803142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003072657,0.0000443606,0.002586799,0.0001004607,0.00004269616,5.581563e-7,0.0007204843,0.00300161,0.9909252,0.00003574972,0.001083676,0.001151137],"study_design_scores_gemma":[0.001780478,0.000393668,0.8547772,0.0002060376,0.00008327524,0.000009464841,0.001962293,0.003810008,0.1334971,0.0002604513,0.003013459,0.0002065704],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943925,0.0006354682,0.0002562024,0.002676272,0.0002495517,0.0007890566,0.00001816078,0.00003614211,0.0009467102],"genre_scores_gemma":[0.9993194,0.00002602013,0.00003618013,0.00005864313,0.0002658473,0.00005071762,0.00004412401,0.00002394551,0.0001751736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8574281,"threshold_uncertainty_score":0.2990841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07951333409104017,"score_gpt":0.3374122803295185,"score_spread":0.2578989462384783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}