{"id":"W2625418525","doi":"10.1111/imm.12777","title":"Metabolic reprogramming in the tumour microenvironment: a hallmark shared by cancer cells and T lymphocytes","year":2017,"lang":"en","type":"review","venue":"Immunology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Ontario Veterinary College, University of Guelph; Terry Fox Research Institute","keywords":"Glutaminolysis; Cancer cell; Immune system; Tumor microenvironment; Biology; Cancer research; Cancer; Glycolysis; Reprogramming; Oxidative phosphorylation; Cell biology; Cancer immunotherapy; Metabolic pathway; Metabolism; Immunology; Immunotherapy; Cell; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003364231,0.0005583293,0.0008675638,0.001282527,0.0002907482,0.001138484,0.0005631273,0.0009804809,0.002693783],"category_scores_gemma":[0.0004059304,0.0001744214,0.0002970771,0.001449007,0.0005936535,0.001200158,0.0007227237,0.001623977,0.001671477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007214655,"about_ca_system_score_gemma":0.000866669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006688441,"about_ca_topic_score_gemma":0.001117529,"domain_scores_codex":[0.9998758,0.00001908485,0.00001398247,0.00002601599,0.0000466548,0.00001857159],"domain_scores_gemma":[0.9997991,0.00006177784,0.00003631506,0.000009402363,0.00006044265,0.00003302783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008171409,0.00003857243,0.0003222066,0.009852612,0.00005718262,0.0003119936,0.00008682806,0.0003327512,0.007406614,0.009876121,0.03312746,0.9385059],"study_design_scores_gemma":[0.000004944385,0.00004354216,0.0006581069,0.001039831,0.00003674431,0.001396687,0.00006375854,0.00004108266,0.001209341,0.002611279,0.9928812,0.00001336963],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002342151,0.9968593,0.0002819322,0.0005140622,0.0002945245,0.000003396062,0.00003304832,0.00001472563,0.001764736],"genre_scores_gemma":[0.001594708,0.9964803,0.0002273313,0.0002999096,0.000205193,0.000007027295,0.00005657989,0.000003107274,0.001125924],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002693783,"threshold_uncertainty_score":0.009011567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02603407521597051,"score_gpt":0.3033781769385683,"score_spread":0.2773441017225978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}