{"id":"W2625687193","doi":"10.1158/1078-0432.ccr-16-3224","title":"Clinical and Genome-Wide Analysis of Cisplatin-Induced Peripheral Neuropathy in Survivors of Adult-Onset Cancer","year":2017,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Common Fund; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Cancer Institute; NIH Office of the Director; National Human Genome Research Institute; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institutes of Health; Université de Genève; University of Pennsylvania; RIKEN; Broad Institute; Harvard University; National Institute on Drug Abuse; University of Miami","keywords":"Medicine; Internal medicine; Cancer; Imputation (statistics); Peripheral neuropathy; Cisplatin; Genome-wide association study; Oncology; Diabetes mellitus; Body mass index; Single-nucleotide polymorphism; Genotype; Chemotherapy; Endocrinology; Genetics; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006009988,0.000183104,0.0002569822,0.0003645181,0.0002629135,0.0003937766,0.0003001413,0.0002192446,0.00131779],"category_scores_gemma":[0.001546354,0.0001319219,0.0002816455,0.001047987,0.0001838722,0.0001663513,0.0003521567,0.0003183557,0.0001381309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002079295,"about_ca_system_score_gemma":0.0002680299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004397705,"about_ca_topic_score_gemma":0.00620554,"domain_scores_codex":[0.9995946,0.0001249485,0.00003883517,0.0001437334,0.0000623372,0.00003553548],"domain_scores_gemma":[0.9990338,0.0001604112,0.0004150296,0.0001426084,0.000135388,0.0001126859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004825443,0.00002267905,0.996074,0.00002393682,0.0001827587,0.0000385766,0.00002603101,0.00008209514,0.000792883,0.00001283798,0.0001777947,0.002084001],"study_design_scores_gemma":[0.00001837974,0.0001058667,0.9992297,0.000004118609,0.0000809996,0.0001089216,0.00003408056,0.0001601286,0.00009308266,0.00001755423,0.0001454076,0.000001709427],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986126,0.0002179864,0.0001249424,0.00002012628,0.000002632702,0.000007855264,0.0008778417,0.000004216204,0.0001316867],"genre_scores_gemma":[0.9987769,0.00007506189,0.00009496752,0.00002536935,0.000003843918,0.000009917278,0.0009174223,0.000002346417,0.00009418966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004397705,"threshold_uncertainty_score":0.00874418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2848085815699349,"score_gpt":0.5834587144445557,"score_spread":0.2986501328746207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}