{"id":"W2625779083","doi":"10.1016/j.envpol.2017.06.024","title":"Time-dependent inhibitory effects of Tris(1, 3-dichloro-2-propyl) phosphate on growth and transcription of genes involved in the GH/IGF axis, but not the HPT axis, in female zebrafish","year":2017,"lang":"en","type":"article","venue":"Environmental Pollution","topic":"Reproductive biology and impacts on aquatic species","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"Carleton University; University of Saskatchewan","funders":"University of Hong Kong; Chinese Academy of Sciences; National Natural Science Foundation of China; Canada Research Chairs; Fundamental Research Funds for the Central Universities; Nanjing University; Huazhong Agricultural University; State Administration of Foreign Experts Affairs; University of Washington","keywords":"Zebrafish; Hypothalamic–pituitary–thyroid axis; Toxicity; Developmental toxicity; Endocrinology; Internal medicine; Biology; Growth factor; Growth inhibition; Gene; Hormone; Insulin-like growth factor; Human fertilization; Chemistry; Thyroid hormones; Cell growth; Genetics; Medicine; Receptor; Fetus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004214389,0.0001381514,0.0001628011,0.00003756901,0.0001021451,0.00001101613,0.0002009151,0.0001287693,0.000007696146],"category_scores_gemma":[0.0001210142,0.00009086826,0.00005517638,0.00002284985,0.0006127047,0.00001862051,0.0000563474,0.0001067922,0.000003812024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000289301,"about_ca_system_score_gemma":0.00001314304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000135747,"about_ca_topic_score_gemma":0.00004827679,"domain_scores_codex":[0.9989995,0.0002088384,0.0002251925,0.0002728094,0.0001456305,0.000147995],"domain_scores_gemma":[0.9993731,0.00002690082,0.0001896254,0.0003848749,0.000003792098,0.00002165918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000383438,0.0001912129,0.01388929,0.0000279644,0.00002268326,0.000001513473,0.0004092187,0.000013255,0.9834034,0.00002546095,0.00002977529,0.001602761],"study_design_scores_gemma":[0.0006911639,0.0003741776,0.3976742,0.00001877679,0.00001057359,0.000001913033,0.0002865742,0.000008971399,0.6007681,0.00004141725,0.00006339599,0.00006066246],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964296,0.002424809,0.00001340951,0.0004214014,0.000118493,0.000453799,0.00002389089,0.000001948472,0.0001126564],"genre_scores_gemma":[0.9981017,0.001496896,0.000009418689,0.0001523609,0.00008517189,0.00002337423,0.00002610922,0.00000889237,0.00009603947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3837849,"threshold_uncertainty_score":0.37055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00896939083713832,"score_gpt":0.2146235145195919,"score_spread":0.2056541236824535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}