{"id":"W2625779083","doi":"10.1016/j.envpol.2017.06.024","title":"Time-dependent inhibitory effects of Tris(1, 3-dichloro-2-propyl) phosphate on growth and transcription of genes involved in the GH/IGF axis, but not the HPT axis, in female zebrafish","year":2017,"lang":"en","type":"article","venue":"Environmental Pollution","topic":"Reproductive biology and impacts on aquatic species","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"Carleton University; University of Saskatchewan","funders":"University of Hong Kong; Chinese Academy of Sciences; National Natural Science Foundation of China; Canada Research Chairs; Fundamental Research Funds for the Central Universities; Nanjing University; Huazhong Agricultural University; State Administration of Foreign Experts Affairs; University of Washington","keywords":"Zebrafish; Hypothalamic–pituitary–thyroid axis; Toxicity; Developmental toxicity; Endocrinology; Internal medicine; Biology; Growth factor; Growth inhibition; Gene; Hormone; Insulin-like growth factor; Human fertilization; Chemistry; Thyroid hormones; Cell growth; Genetics; Medicine; Receptor; Fetus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001442053,0.0003971359,0.0002342405,0.0002175575,0.0001571742,0.000206365,0.0002677724,0.0002990456,0.003679135],"category_scores_gemma":[0.0001843044,0.0002329237,0.0002765096,0.0001509377,0.0004270481,0.0002314356,0.0001514023,0.0006695081,0.0003831396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004756069,"about_ca_system_score_gemma":0.0006012199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006020128,"about_ca_topic_score_gemma":0.01260422,"domain_scores_codex":[0.9999009,0.000009500229,0.000008022579,0.00002346744,0.00001647944,0.00004164853],"domain_scores_gemma":[0.9998223,0.00004501096,0.0000300001,0.00001516556,0.00001944068,0.00006804897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001627991,0.00005407803,0.0001959695,0.00004484107,0.000008061602,0.00006834089,0.00004219935,0.0001015113,0.9964864,0.00009789025,0.0002140096,0.001058572],"study_design_scores_gemma":[0.0001351989,0.001278964,0.01270845,0.000009601406,0.00002500406,0.00007537075,0.000091366,0.0006447653,0.9829947,0.00007905169,0.001939813,0.00001781966],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925528,0.00169784,0.001136274,0.0002862962,0.0001586851,0.000035175,0.001198635,0.0001183533,0.002815767],"genre_scores_gemma":[0.9864845,0.001039828,0.001095125,0.00016555,0.00003638013,0.00008674763,0.001247282,0.00004473936,0.009799932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006020128,"threshold_uncertainty_score":0.01230788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00896939083713832,"score_gpt":0.2146235145195919,"score_spread":0.2056541236824535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}