{"id":"W2625783350","doi":"10.1016/j.virol.2017.06.001","title":"Protein nanoparticle vaccine based on flagellin carrier fused to influenza conserved epitopes confers full protection against influenza A virus challenge","year":2017,"lang":"en","type":"article","venue":"Virology","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Flagellin; Epitope; Virology; Biology; Ectodomain; Fusion protein; Virus; Influenza A virus; Influenza vaccine; Antigenic drift; Antigen; Immune system; Viral matrix protein; Antibody; Microbiology; Recombinant DNA; Gene; Receptor; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001573653,0.0003347598,0.0002791098,0.0001549849,0.0001241244,0.0001883788,0.0001555024,0.0004037207,0.0007452175],"category_scores_gemma":[0.0001306731,0.0001170282,0.0002452806,0.00006448032,0.0001968576,0.0002940513,0.0001684443,0.000470631,0.0002120628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001683509,"about_ca_system_score_gemma":0.0001859325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003882833,"about_ca_topic_score_gemma":0.0003726775,"domain_scores_codex":[0.9999207,0.00001075302,0.00000423007,0.00001654234,0.00001766276,0.00003012134],"domain_scores_gemma":[0.9999362,0.00001750257,0.000008742511,0.000007199422,0.00001460701,0.00001574464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002070429,0.00007706074,0.00006232659,0.00002793184,0.00000487911,0.0000236158,0.000010667,0.00006952629,0.9981385,0.00005840285,0.00004974732,0.001270132],"study_design_scores_gemma":[0.00003151016,0.001532303,0.00114282,0.000005250862,0.0000260662,0.0001514377,0.00001750062,0.0008534826,0.9949542,0.00004720407,0.001234362,0.000003808781],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967037,0.0005797594,0.001646031,0.00007437542,0.00006199648,0.00002001844,0.00004965435,0.00003967654,0.0008247747],"genre_scores_gemma":[0.996864,0.0002740849,0.001055125,0.00006042116,0.00001349546,0.00001083867,0.0001489365,0.000007696245,0.001565478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007452175,"threshold_uncertainty_score":0.002492964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1137177688864557,"score_gpt":0.3679904173898199,"score_spread":0.2542726485033642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}