{"id":"W2625783350","doi":"10.1016/j.virol.2017.06.001","title":"Protein nanoparticle vaccine based on flagellin carrier fused to influenza conserved epitopes confers full protection against influenza A virus challenge","year":2017,"lang":"en","type":"article","venue":"Virology","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Flagellin; Epitope; Virology; Biology; Ectodomain; Fusion protein; Virus; Influenza A virus; Influenza vaccine; Antigenic drift; Antigen; Immune system; Viral matrix protein; Antibody; Microbiology; Recombinant DNA; Gene; Receptor; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009260702,0.0004830734,0.0008803008,0.0004298099,0.0009014239,0.0001040177,0.0004625901,0.00037451,0.0002078692],"category_scores_gemma":[0.002596574,0.0004187954,0.000172327,0.0001937544,0.0003683216,0.0001925598,0.0002764264,0.0007325817,0.0007413481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000224746,"about_ca_system_score_gemma":0.0003092757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006458253,"about_ca_topic_score_gemma":0.00104933,"domain_scores_codex":[0.9964424,0.0003901722,0.0006750335,0.0008485992,0.0005862365,0.001057582],"domain_scores_gemma":[0.9969403,0.0001391548,0.0003107088,0.001649187,0.0004469609,0.0005136799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01380083,0.0004598815,0.002350314,0.0001869917,0.0002028125,0.00029546,0.0005493219,0.0005332014,0.9764224,0.0001631339,0.0003816464,0.004654031],"study_design_scores_gemma":[0.02356621,0.01267073,0.07630692,0.0004447508,0.0001563203,0.00001964462,0.0002194891,0.007130048,0.7438031,0.0001874488,0.1345107,0.0009846288],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843057,0.0002177259,0.00009849318,0.009281511,0.0001802759,0.004184758,0.00006066854,0.0002169344,0.001453938],"genre_scores_gemma":[0.9831113,0.00002315489,0.0002686414,0.01445992,0.000262343,0.001611019,0.000005823799,0.00007943402,0.0001784031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2326193,"threshold_uncertainty_score":0.9998264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1137177688864557,"score_gpt":0.3679904173898199,"score_spread":0.2542726485033642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}