{"id":"W2625921226","doi":"10.1523/jneurosci.3351-16.2017","title":"Astrocyte Transforming Growth Factor Beta 1 Protects Synapses against Aβ Oligomers in Alzheimer's Disease Model","year":2017,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":176,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Astrocyte; Hippocampal formation; Synapse; Neuroscience; Transforming growth factor; Neuroprotection; Dendritic spine; Long-term potentiation; Amyloid beta; Biology; Glial fibrillary acidic protein; Synaptic plasticity; Transforming growth factor beta; Alzheimer's disease; Cell biology; Chemistry; Medicine; Immunology; Internal medicine; Central nervous system; Disease; Receptor; Biochemistry; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001984618,0.0001889792,0.0003420439,0.0003152663,0.0003330059,0.000131275,0.0004502682,0.00003687045,0.000004202213],"category_scores_gemma":[0.0004105395,0.0001386079,0.0002025722,0.0001540583,0.0003193197,0.001018379,0.00006534607,0.000365377,0.000004251345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007298737,"about_ca_system_score_gemma":0.0008259667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001294622,"about_ca_topic_score_gemma":0.000003351443,"domain_scores_codex":[0.9979168,0.00004327534,0.0003764222,0.0002733505,0.0008983843,0.0004917453],"domain_scores_gemma":[0.9981688,0.00003063421,0.0003266985,0.0003410363,0.0001615457,0.0009712845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01206243,0.007424983,0.6558087,0.0006211881,0.002902498,0.04467583,0.001513415,0.003546921,0.2177584,0.00035238,0.0002571684,0.05307605],"study_design_scores_gemma":[0.004978855,0.001276295,0.9531361,0.0006677389,0.0004748076,0.0001931579,0.00004286555,0.01659908,0.02205006,0.0001841425,0.00008231327,0.0003146267],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962794,0.001249025,0.0002102045,0.001319911,0.0001340592,0.0004746787,0.00003187123,0.00001123204,0.0002896167],"genre_scores_gemma":[0.9988008,0.0006561991,0.0002164473,0.0002254949,0.00006235733,0.00001119439,8.284139e-7,0.00001807441,0.000008650124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2973273,"threshold_uncertainty_score":0.5652266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06705629619042326,"score_gpt":0.3388021421519684,"score_spread":0.2717458459615452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}