{"id":"W2625921226","doi":"10.1523/jneurosci.3351-16.2017","title":"Astrocyte Transforming Growth Factor Beta 1 Protects Synapses against Aβ Oligomers in Alzheimer's Disease Model","year":2017,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":176,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Astrocyte; Hippocampal formation; Synapse; Neuroscience; Transforming growth factor; Neuroprotection; Dendritic spine; Long-term potentiation; Amyloid beta; Biology; Glial fibrillary acidic protein; Synaptic plasticity; Transforming growth factor beta; Alzheimer's disease; Cell biology; Chemistry; Medicine; Immunology; Internal medicine; Central nervous system; Disease; Receptor; Biochemistry; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001445507,0.0005951514,0.0006198472,0.0003633319,0.0002136548,0.0002410909,0.0003617907,0.0004455001,0.0009805817],"category_scores_gemma":[0.00007478159,0.0001995392,0.0003963177,0.0002092054,0.000196684,0.0002150458,0.000189761,0.001175172,0.0004955948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001937759,"about_ca_system_score_gemma":0.0003299189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001059474,"about_ca_topic_score_gemma":0.001501043,"domain_scores_codex":[0.9998723,0.00001165569,0.0000162663,0.00002213625,0.00004607839,0.00003157877],"domain_scores_gemma":[0.9999374,0.000003119449,0.00001680723,0.000007150384,0.00001099207,0.00002450316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003904963,0.0002907261,0.0002064731,0.00009126301,0.00001788129,0.0001219219,0.00003288337,0.00007292573,0.9967558,0.00009867565,0.0001302315,0.001790893],"study_design_scores_gemma":[0.0001115436,0.002299922,0.003438829,0.00002146997,0.00007010563,0.0003273629,0.00005252277,0.001302521,0.9893649,0.0001209185,0.002880911,0.000009045392],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908112,0.00301207,0.002711511,0.0002461517,0.0001984728,0.0000925862,0.0005682521,0.0002661106,0.002093685],"genre_scores_gemma":[0.9841998,0.004586934,0.003631353,0.0001298403,0.00004941575,0.0002077384,0.000901179,0.0000300283,0.006263801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001059474,"threshold_uncertainty_score":0.003280401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06705629619042326,"score_gpt":0.3388021421519684,"score_spread":0.2717458459615452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}