{"id":"W2625953191","doi":"10.1101/149070","title":"Mitochondrial DNA SNPs associated with Schizophrenia exhibit Highly Variable Inter-allelic Haplogroup Affiliation and Nuclear Genogeographic Affinity: Bi-Genomic Linkage Disequilibrium raises Major Concerns for Link to Disease","year":2017,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Novo Nordisk Fonden; Familien Hede Nielsens Fond; H. Lundbeck A/S; Jascha Fonden; Augustinus Fonden; Lundbeckfonden; Strategic Research Council; Novo Nordisk","keywords":"Haplogroup; Mitochondrial DNA; Linkage disequilibrium; Genetics; Single-nucleotide polymorphism; Biology; Haplotype; Population stratification; Allele; Human mitochondrial DNA haplogroup; Evolutionary biology; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001468167,0.0001977304,0.0003467312,0.0009443172,0.0005450633,0.0005341582,0.0002280642,0.000250846,0.002260887],"category_scores_gemma":[0.002112147,0.0001282255,0.0002061229,0.001094331,0.00046786,0.0002024934,0.0006632335,0.0003653841,0.0002240627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001757015,"about_ca_system_score_gemma":0.0001882544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001373372,"about_ca_topic_score_gemma":0.003616986,"domain_scores_codex":[0.998871,0.000567838,0.0001238639,0.0002257328,0.0001338374,0.00007764508],"domain_scores_gemma":[0.9985937,0.0005814241,0.0004178239,0.0002556858,0.00006969385,0.00008167697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006331806,0.00004316803,0.9249096,0.00008016563,0.0006392778,0.0006228949,0.001024778,0.0004828667,0.05288866,0.0009735299,0.0003088216,0.01739309],"study_design_scores_gemma":[0.00002186921,0.00006567745,0.9929067,0.00002198426,0.00008348267,0.0007923259,0.0003464986,0.0005486324,0.003116611,0.001349862,0.0007359392,0.00001039238],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970807,0.0003457443,0.001463431,0.000139656,0.000007469665,0.000005283708,0.0004188384,0.00001271814,0.000526046],"genre_scores_gemma":[0.9988708,0.00005424305,0.0006934974,0.0000324594,0.000006384756,0.000004977725,0.0002019595,0.000006814275,0.0001288064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002260887,"threshold_uncertainty_score":0.007764518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01377802642443652,"score_gpt":0.2211064713027212,"score_spread":0.2073284448782847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}