{"id":"W2626064256","doi":"10.1200/jco.2017.35.15_suppl.1067","title":"Treat ER+ight: Canadian prospective observational study in post-menopausal HR+HER2- advanced breast cancer women—First interim analysis (IA).","year":2017,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Novartis (Canada); Hôpital du Sacré-Cœur de Montréal; Université Laval; Grand River Hospital; BC Cancer Agency; Ottawa Hospital; McGill University; Jewish General Hospital","funders":"","keywords":"Medicine; Interim analysis; Adverse effect; Interim; Observational study; Oncology; Internal medicine; Breast cancer; Dosing; Clinical trial; Cancer; Gynecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001641967,0.0005766296,0.0006001164,0.0005398513,0.001174727,0.0008303959,0.001034996,0.0004804756,0.005382374],"category_scores_gemma":[0.002026055,0.0003417333,0.001523694,0.00191605,0.0003765032,0.0003648547,0.0004728605,0.0009680839,0.0005774263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.007289657,"about_ca_system_score_gemma":0.01930846,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.8775576,"about_ca_topic_score_gemma":0.9385561,"domain_scores_codex":[0.9992625,0.00008129385,0.00004103805,0.00009312897,0.0003049591,0.0002170175],"domain_scores_gemma":[0.9987948,0.00008196639,0.0002645791,0.0001276796,0.0004572534,0.000273773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02298099,0.0005564215,0.9049465,0.0006239064,0.003080285,0.0001355427,0.0001953147,0.0008431589,0.001138905,0.0006020018,0.04661768,0.01827933],"study_design_scores_gemma":[0.003561117,0.0008133875,0.9802915,0.00009879562,0.001207469,0.0000754619,0.0001434881,0.0003971831,0.0002722377,0.0001116412,0.01299495,0.00003276614],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7237124,0.003015144,0.0009962206,0.001409534,0.0001122033,0.003278517,0.253166,0.0001117025,0.01419836],"genre_scores_gemma":[0.8484854,0.001774645,0.002890785,0.001531836,0.00007870252,0.002155012,0.1345191,0.00005029689,0.008514094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1224424,"threshold_uncertainty_score":0.246327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04682644740419185,"score_gpt":0.409534119681415,"score_spread":0.3627076722772232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}