{"id":"W2626200828","doi":"10.1200/jco.2017.35.18_suppl.lba3","title":"LATITUDE: A phase III, double-blind, randomized trial of androgen deprivation therapy with abiraterone acetate plus prednisone or placebos in newly diagnosed high-risk metastatic hormone-naive prostate cancer.","year":2017,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Medicine; Abiraterone acetate; Prostate cancer; Androgen deprivation therapy; Internal medicine; Interim analysis; Docetaxel; Prednisone; Randomization; Oncology; Hypokalemia; Randomized controlled trial; Adverse effect; Progression-free survival; Cancer; Urology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009388403,0.001524266,0.001781791,0.0005392779,0.0004215938,0.001004501,0.000915155,0.00112469,0.008611215],"category_scores_gemma":[0.001020601,0.0005974806,0.001179539,0.0004535215,0.0011101,0.0007688917,0.0005185454,0.002075246,0.001277848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000582775,"about_ca_system_score_gemma":0.001416575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001264559,"about_ca_topic_score_gemma":0.003742287,"domain_scores_codex":[0.9996127,0.0002195829,0.00002084953,0.00005117552,0.00003215556,0.00006350701],"domain_scores_gemma":[0.9993851,0.0001256057,0.0001555864,0.00004428041,0.00003008274,0.0002592182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9787773,0.005734038,0.0003873217,0.0004502886,0.0003927061,0.0000218656,0.00003344868,0.0002825611,0.002548081,0.0001004962,0.000603035,0.01066885],"study_design_scores_gemma":[0.9499407,0.04818299,0.0007555972,0.00001777913,0.0001585866,0.0000202196,0.00001623224,0.0001725698,0.000209573,0.00009091294,0.0004276953,0.000007110937],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979533,0.005101425,0.0009185371,0.0006283292,0.0005648042,0.007155489,0.0020874,0.0002936311,0.003717398],"genre_scores_gemma":[0.9750352,0.003676236,0.001946421,0.001258653,0.0005581718,0.0108393,0.001692671,0.0000366031,0.004956729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008611215,"threshold_uncertainty_score":0.02880734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1856420401604156,"score_gpt":0.5032530866104884,"score_spread":0.3176110464500728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}