{"id":"W2626256779","doi":"10.1016/j.celrep.2017.05.042","title":"A UV-Independent Topical Small-Molecule Approach for Melanin Production in Human Skin","year":2017,"lang":"en","type":"article","venue":"Cell Reports","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Cancer Institute; National Institutes of Health; Melanoma Research Alliance; Canadian Institutes of Health Research; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation","keywords":"Microphthalmia-associated transcription factor; Human skin; Melanin; Epidermis (zoology); Skin cancer; Downregulation and upregulation; CREB; Barrier function; Skin whitening; Cell biology; Biology; Transcription factor; Chemistry; Pharmacology; Cancer research; Biochemistry; Cancer; Gene; Genetics; Anatomy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001486279,0.0002733571,0.0001699687,0.0001744826,0.0001432518,0.0002425256,0.0001345626,0.0002216373,0.001099935],"category_scores_gemma":[0.00008962539,0.0001118716,0.0002098955,0.00009357647,0.0001453655,0.0001100765,0.0001372977,0.0004064814,0.0003143534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001702001,"about_ca_system_score_gemma":0.0001615353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002467927,"about_ca_topic_score_gemma":0.0005924592,"domain_scores_codex":[0.9999081,0.00001678178,0.000005864423,0.00002703697,0.00002701519,0.0000151326],"domain_scores_gemma":[0.999954,0.00001207419,0.00001140172,0.000008796141,0.000004776558,0.000008925495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002547064,0.00001753134,0.00002637749,0.00002371608,0.000001996038,0.00001679898,0.000004338723,0.00002941507,0.9985673,0.00004391004,0.00002583222,0.001217232],"study_design_scores_gemma":[0.000005943625,0.0001828931,0.0004213309,0.000002411369,0.000005640184,0.00009135809,0.000003766665,0.0001862722,0.9978074,0.0000102165,0.001280989,0.000001812516],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9641885,0.007503505,0.02144659,0.0002483121,0.0001111195,0.0003371363,0.0005231154,0.0003111782,0.005330439],"genre_scores_gemma":[0.9815036,0.002685718,0.01253468,0.00006669333,0.00001618839,0.0001164093,0.0002488202,0.00002832337,0.002799515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001099935,"threshold_uncertainty_score":0.003679693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0210453913204755,"score_gpt":0.2760402293526784,"score_spread":0.2549948380322029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}