{"id":"W2626271614","doi":"10.1021/acs.jpcb.7b03479","title":"Effect of Urea on G-Quadruplex Stability","year":2017,"lang":"en","type":"article","venue":"The Journal of Physical Chemistry B","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; State Committee of Science","keywords":"Urea; Chemistry; Nucleic acid; G-quadruplex; RNA; Duplex (building); DNA; Biophysics; Function (biology); Solvent; Chemical stability; Biochemistry; Genetics; Biology; Organic chemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003736463,0.0003366116,0.0002950213,0.0001478667,0.000220273,0.0002472459,0.0002228436,0.0002483522,0.001278563],"category_scores_gemma":[0.001003374,0.000132792,0.0001270447,0.0001898611,0.0002615659,0.0002468906,0.0002064559,0.0003906314,0.0001759055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001997009,"about_ca_system_score_gemma":0.0002296354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001496324,"about_ca_topic_score_gemma":0.002061079,"domain_scores_codex":[0.9996878,0.00007750327,0.00002945089,0.0000555694,0.00009359865,0.00005619512],"domain_scores_gemma":[0.9993406,0.00031565,0.0000914695,0.00003231482,0.0001508485,0.00006908195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001802248,0.00005423953,0.0003120082,0.00006948346,0.000009222596,0.00003691858,0.00007369565,0.0001764596,0.996992,0.00002890932,0.00003533158,0.002031489],"study_design_scores_gemma":[0.000004626837,0.0004151249,0.001429243,0.000006213283,0.000007311276,0.00001875299,0.00002511937,0.0006920972,0.9969501,0.000009326559,0.0004366247,0.000005447775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962935,0.001492243,0.0007136969,0.00003720743,0.00003040413,0.00002863769,0.0002756227,0.00004127814,0.001087492],"genre_scores_gemma":[0.9959723,0.000858562,0.002014612,0.00003940937,0.00001325375,0.0000322833,0.0002280703,0.00002733603,0.0008140932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001496324,"threshold_uncertainty_score":0.00427717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007417539327411277,"score_gpt":0.2745946943404826,"score_spread":0.2671771550130713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}